Next Article in Journal
Correction: Farnfield, M.M., et al. Whey Protein Ingestion Activates mTOR-dependent Signalling after Resistance Exercise in Young Men: A Double-Blinded Randomized Controlled Trial. Nutrients 2009, 1, 263-275.
Next Article in Special Issue
Vitamin D status during Pregnancy and Aspects of Offspring Health
Previous Article in Journal
Streptococcus mutans, Caries and Simulation Models
Previous Article in Special Issue
Production of Hesperetin Glycosides by Xanthomonas campestris and Cyclodextrin Glucanotransferase and Their Anti-allergic Activities
Open AccessReview

Vitamin B12 in Health and Disease

Discipline of Nutrition and Metabolism, School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2010, 2(3), 299-316; https://doi.org/10.3390/nu2030299
Received: 2 February 2010 / Accepted: 1 March 2010 / Published: 5 March 2010
(This article belongs to the Special Issue Feature Papers for Vitamins)
Vitamin B12 is essential for DNA synthesis and for cellular energy production. This review aims to outline the metabolism of vitamin B12, and to evaluate the causes and consequences of sub-clinical vitamin B12 deficiency. Vitamin B12 deficiency is common, mainly due to limited dietary intake of animal foods or malabsorption of the vitamin. Vegetarians are at risk of vitamin B12 deficiency as are other groups with low intakes of animal foods or those with restrictive dietary patterns. Malabsorption of vitamin B12 is most commonly seen in the elderly, secondary to gastric achlorhydria. The symptoms of sub-clinical deficiency are subtle and often not recognized. The long-term consequences of sub-clinical deficiency are not fully known but may include adverse effects on pregnancy outcomes, vascular, cognitive, bone and eye health. View Full-Text
Keywords: vitamin B12; physiology; nutrition; adults; chronic disease vitamin B12; physiology; nutrition; adults; chronic disease
MDPI and ACS Style

O’Leary, F.; Samman, S. Vitamin B12 in Health and Disease. Nutrients 2010, 2, 299-316.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop