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Article

Associations between Maternal Iron Supplementation in Pregnancy and Changes in Offspring Size at Birth Reflect Those of Multiple Micronutrient Supplementation

1
Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK
2
MRC Department of Epidemiology, University of Cambridge, Cambridge CB2 0SL, UK
3
Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Louise Brough
Nutrients 2021, 13(7), 2480; https://doi.org/10.3390/nu13072480
Received: 21 May 2021 / Revised: 12 July 2021 / Accepted: 19 July 2021 / Published: 20 July 2021
(This article belongs to the Special Issue Hypertension with Diabetes Mellitus: Dietary Risk and Intervention)
It was previously observed that in a population of a high-income country, dietary multiple micronutrient supplementation in pregnancy was associated with an increased risk of gestational diabetes (GDM) and increased offspring size at birth. In this follow-up study, we investigated whether similar changes are observed with dietary iron supplementation. For this we used the prospective Cambridge Baby Growth Study with records of maternal GDM status, nutrient supplementation, and extensive offspring birth size measurements. Maternal iron supplementation in pregnancy was associated with GDM development (risk ratio 1.67 (1.01–2.77), p = 0.048, n = 677) as well as offspring size and adiposity (n = 844–868) at birth in terms of weight (β’ = 0.078 (0.024–0.133); p = 0.005), head circumference (β’ = 0.060 (0.012–0.107); p = 0.02), body mass index (β’ = 0.067 (0.014–0.119); p = 0.01), and various skinfold thicknesses (β’ = 0.067–0.094; p = 0.03–0.003). In a subset of participants for whom GDM statuses were available, all these associations were attenuated by adjusting for GDM. Iron supplementation also attenuated the associations between multiple micronutrient supplementation and these same measures. These results suggest that iron supplementation may mediate the effects associated with multiple micronutrient supplementation in pregnancy in a high-income country, possibly through the increased risk of developing GDM. View Full-Text
Keywords: fetal growth; gestational diabetes; development; adiposity; minerals; vitamins fetal growth; gestational diabetes; development; adiposity; minerals; vitamins
MDPI and ACS Style

Petry, C.J.; Ong, K.K.; Hughes, I.A.; Dunger, D.B. Associations between Maternal Iron Supplementation in Pregnancy and Changes in Offspring Size at Birth Reflect Those of Multiple Micronutrient Supplementation. Nutrients 2021, 13, 2480. https://doi.org/10.3390/nu13072480

AMA Style

Petry CJ, Ong KK, Hughes IA, Dunger DB. Associations between Maternal Iron Supplementation in Pregnancy and Changes in Offspring Size at Birth Reflect Those of Multiple Micronutrient Supplementation. Nutrients. 2021; 13(7):2480. https://doi.org/10.3390/nu13072480

Chicago/Turabian Style

Petry, Clive J., Ken K. Ong, Ieuan A. Hughes, and David B. Dunger. 2021. "Associations between Maternal Iron Supplementation in Pregnancy and Changes in Offspring Size at Birth Reflect Those of Multiple Micronutrient Supplementation" Nutrients 13, no. 7: 2480. https://doi.org/10.3390/nu13072480

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