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Article

Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea

1
Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan
2
Department of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Eva Untersmayr and Peter M. Abuja
Nutrients 2021, 13(6), 2029; https://doi.org/10.3390/nu13062029
Received: 29 April 2021 / Revised: 9 June 2021 / Accepted: 10 June 2021 / Published: 12 June 2021
(This article belongs to the Special Issue Connection between Microbiome, Lifestyle and Diet)
While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual’s susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that Escherichia coli of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the E. coli sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health. View Full-Text
Keywords: gut microbiota; sugar alcohol; diarrhea gut microbiota; sugar alcohol; diarrhea
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MDPI and ACS Style

Hattori, K.; Akiyama, M.; Seki, N.; Yakabe, K.; Hase, K.; Kim, Y.-G. Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea. Nutrients 2021, 13, 2029. https://doi.org/10.3390/nu13062029

AMA Style

Hattori K, Akiyama M, Seki N, Yakabe K, Hase K, Kim Y-G. Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea. Nutrients. 2021; 13(6):2029. https://doi.org/10.3390/nu13062029

Chicago/Turabian Style

Hattori, Kouya, Masahiro Akiyama, Natsumi Seki, Kyosuke Yakabe, Koji Hase, and Yun-Gi Kim. 2021. "Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea" Nutrients 13, no. 6: 2029. https://doi.org/10.3390/nu13062029

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