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Nutrients
Volume 13
Issue 3
10.3390/nu13030718
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Article
Peer-Review Record

Dairy-Derived Emulsifiers in Infant Formula Show Marginal Effects on the Plasma Lipid Profile and Brain Structure in Preterm Piglets Relative to Soy Lecithin

Nutrients 2021, 13(3), 718; https://doi.org/10.3390/nu13030718
by Nicole L. Henriksen 1, Karoline Aasmul-Olsen 1, Ramakrishnan Venkatasubramanian 2, Mikkel K. E. Nygaard 3, Richard R. Sprenger 4, Anne B. Heckmann 5, Marie S. Ostenfeld 5, Christer S. Ejsing 4, Simon F. Eskildsen 3, Anette Müllertz 6, Per T. Sangild 1, Stine B. Bering 1 and Thomas Thymann 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Nutrients 2021, 13(3), 718; https://doi.org/10.3390/nu13030718
Submission received: 25 January 2021 / Revised: 15 February 2021 / Accepted: 18 February 2021 / Published: 24 February 2021
(This article belongs to the Special Issue The Effect of Lipid Nutrients on Brain Function)

Round 1

Reviewer 1 Report

Thank you very much for sending this excellent manuscript to Nutrients. The paper, in my opinion, is very well written and structured, with high quality introduction and discussion. The methodology, although not an expert in experimental research myself, seems quite appropriate.

I only have a couple of minor issues:

In Figure 3, it is not clear what differences are indicated by the lower-case letters “a” and “b” (between which groups). Please, clarify it.

In the results section, lines 322 – 325 and at the end of the manuscript (lines 517 - 520), a Table S5A, S5B, and S5C is mentioned, but such a Table is not provided.

Author Response

Please see attachment. A word document with responses to both reviewers

Author Response File: Author Response.docx

Reviewer 2 Report

This is a wonderfully clear, well-thought-out study on a physiologically relevant question.

Minor comments:

  1. Why was the protocol duration determined to be 19 days?
  2. Is the pig brain relevant to the preterm infant? Conrad/Dobbing/Odle speak to volume, what about the microcellular development and differentiation, such as myelination patterns? The preterm pig walks on its own readily after birth, so I imagine this does reflect a different maturation pattern at birth compared to humans. 
  3. Did antibiotic usage and the presence of diarrhea differ by group? Theoretically, antibiotic exposure can be related to differences in the microbiome and there is emerging literature on the role of the microbiome in lipid metabolism.
  4. It would be helpful to see the distribution of deaths by group. Altered lipid hydrolysis has been shown to increase the risk of NEC. Would be of interest to see that deaths/cause of death is not different by group.

 

Author Response

Please see attachment. A word document with responses to both reviewers

Author Response File: Author Response.docx

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