Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?

Zec, Manja M.; Krga, Irena; Stojković, Ljiljana; Živković, Maja; Pokimica, Biljana; Stanković, Aleksandra; Glibetic, Maria

doi:10.3390/nu13020296

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Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?

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Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia

Laboratory for Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia

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Academic Editor: Floyd H. Chilton

Nutrients 2021, 13(2), 296; https://doi.org/10.3390/nu13020296

Received: 3 December 2020 / Revised: 30 December 2020 / Accepted: 5 January 2021 / Published: 21 January 2021

(This article belongs to the Special Issue The Impact of the Modern Western Human Diet on Inflammatory Diseases: Emerging Strategies for Prevention and Treatment)

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Abstract

Dietary polyphenols promote cardiometabolic health and are linked with long-chain polyunsaturated fatty acids in plasma phospholipids (LC-PUFA). The FADS2 polymorphisms are associated with LC-PUFA metabolism and overweight/obesity. This 4-week study examined the link between polyphenol intake, FADS2 variants (rs174593, rs174616, rs174576) and obesity in 62 overweight adults (BMI ≥ 25), allocated to consume 100 mL daily of either: Aronia juice, a rich source of polyphenols, with 1177.11 mg polyphenols (expressed as gallic acid equivalents)/100 mL (AJ, n = 22), Aronia juice with 294.28 mg polyphenols/100 mL (MJ, n = 20), or nutritionally matched polyphenol-lacking placebo as a control (PLB, n = 20). We analyzed LC-PUFA (% of total pool) by gas chromatography and FADS2 variants by real-time PCR. Four-week changes in LC-PUFA, BMI, and body weight were included in statistical models, controlling for gender and PUFA intake. Only upon AJ and MJ, the presence of FADS2 variant alleles affected changes in linoleic, arachidonic, and eicosapentaenoic acid (EPA). Upon MJ treatment, changes in EPA were inversely linked with changes in BMI (β= −0.73, p = 0.029) and weight gain (β= −2.17, p = 0.024). Only in subjects drinking AJ, the link between changes in EPA and anthropometric indices was modified by the rs174576 variant allele. Our results indicate the interaction between FADS2, fatty acid metabolism, and polyphenol intake in overweight subjects. View Full-Text

Keywords: polyphenols; Aronia; long-chain polyunsaturated fatty acids; FADS2; obesity; gene-dietary interaction

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Zec, M.M.; Krga, I.; Stojković, L.; Živković, M.; Pokimica, B.; Stanković, A.; Glibetic, M. Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight? Nutrients 2021, 13, 296. https://doi.org/10.3390/nu13020296

AMA Style

Zec MM, Krga I, Stojković L, Živković M, Pokimica B, Stanković A, Glibetic M. Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight? Nutrients. 2021; 13(2):296. https://doi.org/10.3390/nu13020296

Chicago/Turabian Style

Zec, Manja M., Irena Krga, Ljiljana Stojković, Maja Živković, Biljana Pokimica, Aleksandra Stanković, and Maria Glibetic. 2021. "Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?" Nutrients 13, no. 2: 296. https://doi.org/10.3390/nu13020296

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Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?

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