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Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease

1
Institute of Food Science Research (CIAL), CSIC-UAM, c/Nicolás Cabrera 9, Campus de Cantoblanco, 28049 Madrid, Spain
2
Institute of Tropical Medicine, Unit Noncommunicable Diseases, Natl Str 155, B-2000 Antwerp, Belgium
3
Biomedical Research Center of La Rioja (CIBIR) c/Piqueras 98, 26006 Logroño, Spain
4
Institute of Grapevine and Wine Sciences (ICVV), CSIC-University of La Rioja-Government of La Rioja, Autovía del Camino de Santiago LO-20 Exit 13, 26007 Logroño, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3082; https://doi.org/10.3390/nu12103082
Received: 8 September 2020 / Revised: 3 October 2020 / Accepted: 5 October 2020 / Published: 10 October 2020
(This article belongs to the Special Issue Impact of Dietary Components on Gut Microbiota)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to the most common form of dementia in elderly people. Modifiable dietary and lifestyle factors could either accelerate or ameliorate the aging process and the risk of developing AD and other age-related morbidities. Emerging evidence also reports a potential link between oral and gut microbiota alterations and AD. Dietary polyphenols, in particular wine polyphenols, are a major diver of oral and gut microbiota composition and function. Consequently, wine polyphenols health effects, mediated as a function of the individual’s oral and gut microbiome are considered one of the recent greatest challenges in the field of neurodegenerative diseases as a promising strategy to prevent or slow down AD progression. This review highlights current knowledge on the link of oral and intestinal microbiome and the interaction between wine polyphenols and microbiota in the context of AD. Furthermore, the extent to which mechanisms bacteria and polyphenols and its microbial metabolites exert their action on communication pathways between the brain and the microbiota, as well as the impact of the molecular mediators to these interactions on AD patients, are described. View Full-Text
Keywords: Alzheimer’s disease; diet; wine; microbiome modulation; oral and gut microbiota; polyphenol metabolites Alzheimer’s disease; diet; wine; microbiome modulation; oral and gut microbiota; polyphenol metabolites
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MDPI and ACS Style

Moreno-Arribas, M.V.; Bartolomé, B.; Peñalvo, J.L.; Pérez-Matute, P.; Motilva, M.J. Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease. Nutrients 2020, 12, 3082. https://doi.org/10.3390/nu12103082

AMA Style

Moreno-Arribas MV, Bartolomé B, Peñalvo JL, Pérez-Matute P, Motilva MJ. Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease. Nutrients. 2020; 12(10):3082. https://doi.org/10.3390/nu12103082

Chicago/Turabian Style

Moreno-Arribas, M. Victoria, Begoña Bartolomé, José L. Peñalvo, Patricia Pérez-Matute, and Maria José Motilva. 2020. "Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease" Nutrients 12, no. 10: 3082. https://doi.org/10.3390/nu12103082

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