Next Article in Journal
Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke
Previous Article in Journal
Endemic Goiter and Iodine Prophylaxis in Calabria, a Region of Southern Italy: Past and Present
Open AccessArticle

Fermentation of Blackberry with L. plantarum JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling

1
Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea
2
Chebigen Co. Ltd., Jeonju 54853, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2429; https://doi.org/10.3390/nu11102429
Received: 11 September 2019 / Revised: 27 September 2019 / Accepted: 8 October 2019 / Published: 11 October 2019
Chronic and extensive exposure of ultraviolet (UV)-irradiation causes human skin sunburn, inflammation, or photoaging, which is associated with downregulated collagen synthesis. This study investigated the effects of fermented blackberry (Rubus fruticosus B., FBB) by Lactobacillus plantarum JBMI F5 (LP) on UVB-induced photoaging in human foreskin fibroblast (Hs68) as well as in SKH-1 hairless mice. FBB pretreatment inhibited UVB-mediated type-1 procollagen degradation, matrix metalloproteinase (MMP)-1 and MMP-2 protein expression, and suppressed nuclear factor-κB (NF-κB) activation as well as mitogen-activated protein kinase (MAPK) phosphorylation in Hs68. In addition, FBB administration diminished the wrinkle formation in dorsal skin and epidermal thickening in UVB-irradiated hairless mice. Moreover, UVB-induced Type-1 procollagen reduction and antioxidant enzyme inactivation were reversed by FBB administration. These results suggest that FBB may have antiphotoaging effects on UVB-induced wrinkle formation by maintaining the extracellular matrix density in the dermis, which occurs via regulation of reactive oxygen species and related MAPK and NF-κB signaling. Therefore, FBB can be a potential candidate for protecting skin aging against UV irradiation. View Full-Text
Keywords: skin aging; photoaging; fermented blackberry; Lactobacillus plantarum; type I procollagen; MMPs skin aging; photoaging; fermented blackberry; Lactobacillus plantarum; type I procollagen; MMPs
Show Figures

Figure 1

MDPI and ACS Style

Kim, H.-R.; Jeong, D.-H.; Kim, S.; Lee, S.-W.; Sin, H.-S.; Yu, K.-Y.; Jeong, S.-I.; Kim, S.-Y. Fermentation of Blackberry with L. plantarum JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling. Nutrients 2019, 11, 2429.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop