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Open AccessArticle

Yirui Capsules Alleviate Atherosclerosis by Improving the Lipid Profile and Reducing Inflammation in Apolipoprotein E-Deficient Mice

by Jiqu Xu 1,2,3,†, Zumeng Xia 4,*,†, Shuang Rong 5, Hui Gao 6, Wei Yang 6, Jieliang Li 7, Congcong Ma 1,2,3, Qianchun Deng 1,2,3, Qingde Huang 1,2,3, Lingyun Xiao 4 and Fenghong Huang 1,2,3,*
1
Department of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China
2
Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China
3
Key Laboratory of Oilseeds processing, Ministry of Agriculture, Wuhan 430062, China
4
Functional Oil Laboratory Associated by Oil Crops Research Institute, Chinese Academy of Agricultural Sciences and Infinitus (China) Company Ltd., Guangzhou 510663, China
5
Department of Nutrition and Food Hygiene, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
6
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
7
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(2), 142; https://doi.org/10.3390/nu10020142
Received: 29 November 2017 / Revised: 8 January 2018 / Accepted: 16 January 2018 / Published: 29 January 2018
Atherosclerosis (AS) is the main cause of cardiovascular diseases. This study investigated Yirui (YR) capsules, whose ingredients are available in health food stores, against AS and the underlying mechanisms. Male apolipoprotein E-deficient mice fed a high-fat diet for 10 weeks developed severe aortic lesions, but YR significantly decreased the plaque area in the total aorta and aortic root. YR affected the serum lipid profile by significantly reducing total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and oxidative modification of LDL-C (Ox-LDL) levels. In addition, multi-cytokine analysis revealed that higher serum levels of interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β), interleukin-3 (IL-3), interleukin-6 (IL-6), interleukin-27 (IL-27), tumor necrosis factor alpha, interferon gamma, and regulated on activation, normal T cell expressed and secreted (RANTES), which were induced by a high-fat diet, declined with YR treatment. These results suggest that YR reduces the atherosclerotic plaque burden, thereby alleviating AS by modulating the lipid profile and inhibiting inflammation. View Full-Text
Keywords: Yirui capsule; atherosclerosis; lipid profile; inflammation Yirui capsule; atherosclerosis; lipid profile; inflammation
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Xu, J.; Xia, Z.; Rong, S.; Gao, H.; Yang, W.; Li, J.; Ma, C.; Deng, Q.; Huang, Q.; Xiao, L.; Huang, F. Yirui Capsules Alleviate Atherosclerosis by Improving the Lipid Profile and Reducing Inflammation in Apolipoprotein E-Deficient Mice. Nutrients 2018, 10, 142.

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