Serum Triglycerides and Atherosclerotic Cardiovascular Disease: Insights from Clinical and Genetic Studies

Round 1

Reviewer 1 Report

This review is written very well. It reflects the actual opinion with respect to the role of triglycerides in the atherogenesis.

Some more important intervention studies (Helsinki Heart Study, FIELD, ACCORD, DAIS) should have been mentioned.

Minor comments

Page 1 Line 37: This may be because there are no randomized controlled trials (RCTs) supporting causal associations between triglycerides and ASCVD outcomes. – the FIELD and the ACCORD studies represent randomized studies showing an effect of a fibrate in patients with elevated triglycerides and low HDL-C

Page 2 Line 44: They are also present  in the blood to enable bidirectional transference of adipose fat and blood glucose from the liver – triglycerides are not involved in the transport of glucose

Page 2 Line 65: Accumulating experimental evidence suggests that  triglyceride-rich lipoproteins – “triglyceride-rich lipoproteins” should be replaced by VLDL

Page 3 Line 93: Figure 2. Schema of randomized controlled – Scheme

Table 1 – probably Reference 16 – no background and no explanation of these data is given; the interpretation in the text is not clearly reflected in the Table

Page 5 Line 133: If  this Friedewald equation is used – the Friedewald equation

Paragraph 6: the authors should discuss the role of tests checking the postprandial increase of triglycerides

Page 6 Line 160: LPL is one of the major drivers of triglyceride-rich lipoproteins – drivers of the catabolism of triglyceride-rich lipoproteins

Reference 1: 1. Trialists C.T.. – wrong authors

Page 9 Line 331: of atherogenic dyslipidaemiaCardiovasc Diabetol – spelling error

Author Response

Author Response File: Author Response.docx

Reviewer 2 Report

The author summarized the recently findings which supported the causal association between serum triglycerides and atherosclerotic cardiovascular disease (ASCVD) by clinical and Mendelian randomization studies.

1.      Page 2 line 72, FH should be defined when it first time show up in the text.

2.      It is better to have the description/explanation (legend) for Table 2 and Figure 4.

3.      It is better to provide more description for every figure and table in the text, not just one sentence conclusion. It is difficult to understand how you got this conclusion from the present figure and table.

Author Response

Author Response File: Author Response.docx