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Case Report

Kidney Failure and Abdominal Discomfort as Initial Signs of Extramedullary Acute Myelogenous Leukemia

1
Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway
2
Institute of Medical Science, University of Bergen, N-5021 Bergen, Norway
3
Department of Pathology, Haukeland University Hospital, N-5021 Bergen, Norway
4
Department of Radiology and Nuclear Medicine, Haukeland University Hospital, N-5021 Bergen, Norway
5
Institute of Clinical Science, University of Bergen, N-5021 Bergen, Norway
*
Author to whom correspondence should be addressed.
Clin. Pract. 2021, 11(3), 459-466; https://doi.org/10.3390/clinpract11030061
Received: 15 June 2021 / Revised: 10 July 2021 / Accepted: 13 July 2021 / Published: 22 July 2021
Although rare, acute myelogenous leukemia (AML) can include extramedullary manifestations, sometimes presenting as a solid tumor called a myeloid sarcoma. Myeloid sarcoma can be the cause of the initial presenting complaint before AML diagnosis, or may be detected as a sign of disease-relapse after treatment. Here, we report a case in which the initial presentation included abdominal discomfort and signs of kidney failure. Further investigation revealed signs of unilateral hydronephrosis. Due to a diagnostic delay, the patient was diagnosed with AML with extramedullary manifestation only after the development of full-blown leukemia. Biopsy of the compressive tumor confirmed an extramedullary myeloid sarcoma, and [18F]-FDG-PET/CT proved useful for patient diagnosis and follow-up. This case report illustrates the importance of thorough examination and diagnosis, as a serious underlying disease with a rare cause can debut with an unusual presentation. View Full-Text
Keywords: kidney failure; hydronephrosis; acute myelogenous leukemia; PET kidney failure; hydronephrosis; acute myelogenous leukemia; PET
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MDPI and ACS Style

Steinfeld, P.F.; Knoop, T.; Trovik, L.H.; Gjelberg, H.K.; Haslerud, T.M.; Reikvam, H. Kidney Failure and Abdominal Discomfort as Initial Signs of Extramedullary Acute Myelogenous Leukemia. Clin. Pract. 2021, 11, 459-466. https://doi.org/10.3390/clinpract11030061

AMA Style

Steinfeld PF, Knoop T, Trovik LH, Gjelberg HK, Haslerud TM, Reikvam H. Kidney Failure and Abdominal Discomfort as Initial Signs of Extramedullary Acute Myelogenous Leukemia. Clinics and Practice. 2021; 11(3):459-466. https://doi.org/10.3390/clinpract11030061

Chicago/Turabian Style

Steinfeld, Peter F., Thomas Knoop, Linn H. Trovik, Hilde K. Gjelberg, Torjan M. Haslerud, and Håkon Reikvam. 2021. "Kidney Failure and Abdominal Discomfort as Initial Signs of Extramedullary Acute Myelogenous Leukemia" Clinics and Practice 11, no. 3: 459-466. https://doi.org/10.3390/clinpract11030061

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