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Clinics and Practice
Volume 1
Issue 3
10.4081/cp.2011.e78
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Severe Hypothyroidism Associated with the Degree of Edema in a Patient with Nephrosis

by
Hiroyuki Kinoshita
*,
Amiko Ishii
,
Akiko Hayakawa
,
Mutsuko Yasuda
,
Seiji Inoshita
and
Fumiatsu Yakushiji
Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
*
Author to whom correspondence should be addressed.
Clin. Pract. 2011, 1(3), e78; https://doi.org/10.4081/cp.2011.e78
Submission received: 6 August 2011 / Revised: 6 August 2011 / Accepted: 27 September 2011 / Published: 13 October 2011

Abstract

We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30-50% of the plasma. The concentrations of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were approximately 30-50% of the plasma. Hypothyroidism was associated with the degree of edema. After improving systemic edema, proteinuria remained unchanged but the patient did not require levothyroxine. We speculate that the large amount of transudation of thyroid hormones with their carrier proteins from the blood vessels to the third space (edema and pleural effusion), thereby reducing thyroid hormones in the plasma, was associated with hypothyroidism.
Keywords: thyroid hormones; thyroid hormonebinding proteins; hypothyroidism; pleural effusion; edema; nephrotic syndrome thyroid hormones; thyroid hormonebinding proteins; hypothyroidism; pleural effusion; edema; nephrotic syndrome

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MDPI and ACS Style

Kinoshita, H.; Ishii, A.; Hayakawa, A.; Yasuda, M.; Inoshita, S.; Yakushiji, F. Severe Hypothyroidism Associated with the Degree of Edema in a Patient with Nephrosis. Clin. Pract. 2011, 1, e78. https://doi.org/10.4081/cp.2011.e78

AMA Style

Kinoshita H, Ishii A, Hayakawa A, Yasuda M, Inoshita S, Yakushiji F. Severe Hypothyroidism Associated with the Degree of Edema in a Patient with Nephrosis. Clinics and Practice. 2011; 1(3):e78. https://doi.org/10.4081/cp.2011.e78

Chicago/Turabian Style

Kinoshita, Hiroyuki, Amiko Ishii, Akiko Hayakawa, Mutsuko Yasuda, Seiji Inoshita, and Fumiatsu Yakushiji. 2011. "Severe Hypothyroidism Associated with the Degree of Edema in a Patient with Nephrosis" Clinics and Practice 1, no. 3: e78. https://doi.org/10.4081/cp.2011.e78

APA Style

Kinoshita, H., Ishii, A., Hayakawa, A., Yasuda, M., Inoshita, S., & Yakushiji, F. (2011). Severe Hypothyroidism Associated with the Degree of Edema in a Patient with Nephrosis. Clinics and Practice, 1(3), e78. https://doi.org/10.4081/cp.2011.e78

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