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Thalassemia Reports
Volume 4
Issue 2
10.4081/thal.2014.1832
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Review

HbA2 Measurements in β-Thalassemia and in Other Conditions

by
Giovanni Ivaldi
1,
Giuseppina Barberio
2,
Cornelis L. Harteveld
3 and
Piero Giordano
3,*
1
Laboratorio di Genetica Umana, Settore Microcitemia, Ospedali Galliera, Genova, Italy
2
Medicina di Laboratorio, Ospedale di Treviso, Azienda U.L.S.S. N.9, Treviso, Italy
3
The Hemoglobinopathies Laboratory, Departments of Human and Clinical Genetics, Leiden University Medical Center, O&O Building, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2014, 4(2), 1832; https://doi.org/10.4081/thal.2014.1832
Submission received: 20 July 2013 / Revised: 22 November 2013 / Accepted: 11 February 2014 / Published: 29 September 2014

Abstract

Quite a few papers have been written on the significance of elevated hemoglobin (Hb) A2 as a parameter for the diagnosis of β-thalassemia trait, on the cutoff values to be used in diagnostics and on the significance and effects of factors reducing or elevating the expression of HbA2 and last but not least on the need for reliable measurement methods and precise calibrations with accurate standards. However, little has been published on the causes that elevate or reduce the HbA2 levels in β- and a-thalassemia and in other conditions. For a better understanding of the value of a precise measurement of this parameter we summarize and elucidate in this review the direct and indirect mechanisms that cause the variations in HbA2 expression and that influence the value of this parameter in particular conditions. We conclude by explaining the advantages and disadvantages of trusting on a precise measurement in the complete diagnostic contest.
Keywords: hemoglobin A2; β-thalassemia hemoglobin A2; β-thalassemia

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MDPI and ACS Style

Ivaldi, G.; Barberio, G.; Harteveld, C.L.; Giordano, P. HbA2 Measurements in β-Thalassemia and in Other Conditions. Thalass. Rep. 2014, 4, 1832. https://doi.org/10.4081/thal.2014.1832

AMA Style

Ivaldi G, Barberio G, Harteveld CL, Giordano P. HbA2 Measurements in β-Thalassemia and in Other Conditions. Thalassemia Reports. 2014; 4(2):1832. https://doi.org/10.4081/thal.2014.1832

Chicago/Turabian Style

Ivaldi, Giovanni, Giuseppina Barberio, Cornelis L. Harteveld, and Piero Giordano. 2014. "HbA2 Measurements in β-Thalassemia and in Other Conditions" Thalassemia Reports 4, no. 2: 1832. https://doi.org/10.4081/thal.2014.1832

APA Style

Ivaldi, G., Barberio, G., Harteveld, C. L., & Giordano, P. (2014). HbA2 Measurements in β-Thalassemia and in Other Conditions. Thalassemia Reports, 4(2), 1832. https://doi.org/10.4081/thal.2014.1832

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