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Hematology Reports
Volume 9
Issue 4
10.4081/hr.2017.7201
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Case Report

PRDI-BF1 and PRDI-BF1β Isoform Expressions Correlate with Disease Status in Multiple Myeloma Patients

by
Gabriele Buda
*,
Francesca Guerrini
,
Sara Galimberti
,
Enrico Orciuolo
,
Simone Pacini
,
Elisa Mazzantini
and
Mario Petrini
Department of Clinical and Experimental Medicine, U.O. Hematology, University of Pisa, 56124 Pisa, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(4), 7201; https://doi.org/10.4081/hr.2017.7201
Submission received: 23 April 2017 / Revised: 9 October 2017 / Accepted: 9 October 2017 / Published: 22 December 2017

Abstract

Human positive regulatory domain I binding factor 1 (PRDI-BF1 or BLIMP-1) is a transcription factor that acts as a master regulator and has crucial roles in the control of differentiation and in maintaining survival of plasma cells (PC). The PRDM1 gene, which codifies for PRDI-BF1, contains an alternative promoter capable of generating a PRDI-BF1 deleted protein (called PRDI-BF1β), which lacks 101 amino acids comprising most of the regulatory domain. PRDI-BF1β has been detected in relevant quantities especially in multiple myeloma cell lines (U266 and NCI- H929). The first aim of the study was to compare, using real time polymerase chain reaction (RT-PCR), the levels of PRDI-BF1 and PRDI-BF1β in myeloma patients and in normal human bone marrow. The second step was the examination of the expression of PRDI-BF1 and PRDI-BF1β isoform depending on disease status and treatment response. We demonstrate the correlation of PRDI-BF1 and the shorter PRDI-BF1β isoform protein levels with the clinical evolution and the management of myeloma patients.
Keywords: hematology; multiple myeloma; multi drug resistance hematology; multiple myeloma; multi drug resistance

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MDPI and ACS Style

Buda, G.; Guerrini, F.; Galimberti, S.; Orciuolo, E.; Pacini, S.; Mazzantini, E.; Petrini, M. PRDI-BF1 and PRDI-BF1β Isoform Expressions Correlate with Disease Status in Multiple Myeloma Patients. Hematol. Rep. 2017, 9, 7201. https://doi.org/10.4081/hr.2017.7201

AMA Style

Buda G, Guerrini F, Galimberti S, Orciuolo E, Pacini S, Mazzantini E, Petrini M. PRDI-BF1 and PRDI-BF1β Isoform Expressions Correlate with Disease Status in Multiple Myeloma Patients. Hematology Reports. 2017; 9(4):7201. https://doi.org/10.4081/hr.2017.7201

Chicago/Turabian Style

Buda, Gabriele, Francesca Guerrini, Sara Galimberti, Enrico Orciuolo, Simone Pacini, Elisa Mazzantini, and Mario Petrini. 2017. "PRDI-BF1 and PRDI-BF1β Isoform Expressions Correlate with Disease Status in Multiple Myeloma Patients" Hematology Reports 9, no. 4: 7201. https://doi.org/10.4081/hr.2017.7201

APA Style

Buda, G., Guerrini, F., Galimberti, S., Orciuolo, E., Pacini, S., Mazzantini, E., & Petrini, M. (2017). PRDI-BF1 and PRDI-BF1β Isoform Expressions Correlate with Disease Status in Multiple Myeloma Patients. Hematology Reports, 9(4), 7201. https://doi.org/10.4081/hr.2017.7201

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