Next Article in Journal
Emergency Management of Major Bleeding in a Case of Maxillofacial Trauma and Anticoagulation: Utility of Prothrombin Complex Concentrates in the Shock Room
Previous Article in Journal
Central Neurotoxicity of Immunomodulatory Drugs in Multiple Myeloma
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 7
Issue 1
10.4081/hr.2015.5632
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Interferon α Therapy in Patients with Chronic Hepatitis C Infection: Quality of Life and Depression

by
Ciro Conversano
1,
Claudia Carmassi
1,*,
Marina Carlini
1,
Giulia Casu
2,
Paola Gremigni
2 and
Liliana Dell’Osso
1
1
Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
2
Department of Psychology, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2015, 7(1), 5632; https://doi.org/10.4081/hr.2015.5632
Submission received: 11 September 2014 / Revised: 6 January 2015 / Accepted: 23 January 2015 / Published: 3 March 2015

Abstract

Health-related quality of life was examined in 49 patients with hepatitis C virus with no psychiatric history who received interferon (IFN)-α treatment. Quality of life was assessed at baseline, at 3-time points during IFN-α therapy and at 1-6 month follow-up, using SF-36. Hepatitis C virus patients showed poorer physical functioning and better social and mental functioning than a normal population. Significant decreases from baseline SF-36 scores were observed at an early phase of treatment. Six patients developed major depression during IFN-α treatment. At baseline, they had reported more bodily pain than patients who did not develop depression during treatment. Planned contrasts revealed that worsening in some dimensions of quality of life at 2 months was greater in depressed than in non-depressed patients. Results suggest that depressive symptoms should be accurately monitored during IFN-α therapy even in patients with no psychiatric history, especially if they present with bodily pain.
Keywords: depression; HCV; interferon; quality of life depression; HCV; interferon; quality of life

Share and Cite

MDPI and ACS Style

Conversano, C.; Carmassi, C.; Carlini, M.; Casu, G.; Gremigni, P.; Dell’Osso, L. Interferon α Therapy in Patients with Chronic Hepatitis C Infection: Quality of Life and Depression. Hematol. Rep. 2015, 7, 5632. https://doi.org/10.4081/hr.2015.5632

AMA Style

Conversano C, Carmassi C, Carlini M, Casu G, Gremigni P, Dell’Osso L. Interferon α Therapy in Patients with Chronic Hepatitis C Infection: Quality of Life and Depression. Hematology Reports. 2015; 7(1):5632. https://doi.org/10.4081/hr.2015.5632

Chicago/Turabian Style

Conversano, Ciro, Claudia Carmassi, Marina Carlini, Giulia Casu, Paola Gremigni, and Liliana Dell’Osso. 2015. "Interferon α Therapy in Patients with Chronic Hepatitis C Infection: Quality of Life and Depression" Hematology Reports 7, no. 1: 5632. https://doi.org/10.4081/hr.2015.5632

APA Style

Conversano, C., Carmassi, C., Carlini, M., Casu, G., Gremigni, P., & Dell’Osso, L. (2015). Interferon α Therapy in Patients with Chronic Hepatitis C Infection: Quality of Life and Depression. Hematology Reports, 7(1), 5632. https://doi.org/10.4081/hr.2015.5632

Article Metrics

Back to TopTop