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Hematology Reports
Volume 6
Issue 1
10.4081/hr.2014.5159
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Article

Isolated Hemolytic Anemia: An Unusual Manifestation of Occult Malignancy

by
Matthew J. Butler
1,*,
Ming Yin
1 and
Fahd Quddus
2
1
Internal Medicine Residency Program, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, USA
2
Department of Hematology and Oncology, Geisinger Medical Center, Danville, PA 17822, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2014, 6(1), 5159; https://doi.org/10.4081/hr.2014.5159
Submission received: 6 November 2013 / Revised: 24 December 2013 / Accepted: 12 January 2014 / Published: 5 February 2014

Abstract

Hemolysis is an uncommon and usually late complication of malignancy, and very rarely the presenting feature. Cancer-associated hemolysis may be immune-mediated, or may result from thrombotic microangiopathy accompanied by thrombocytopenia. We describe an unusual case of isolated hemolysis in the setting of occult metastatic breast cancer. The patient initially presented with symptomatic anemia, with evidence of hemolysis but with negative direct antiglobulin testing and a normal platelet count. Subsequent investigation discovered metastatic adenocarcinoma of the breast involving bone marrow. Hemolysis worsened despite initial treatment with cytotoxic chemotherapy and a trial of corticosteroids, but later resolved with aromatase inhibitor therapy.
Keywords: hemolysis; hemolytic anemia; malignancy; cancer hemolysis; hemolytic anemia; malignancy; cancer

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MDPI and ACS Style

Butler, M.J.; Yin, M.; Quddus, F. Isolated Hemolytic Anemia: An Unusual Manifestation of Occult Malignancy. Hematol. Rep. 2014, 6, 5159. https://doi.org/10.4081/hr.2014.5159

AMA Style

Butler MJ, Yin M, Quddus F. Isolated Hemolytic Anemia: An Unusual Manifestation of Occult Malignancy. Hematology Reports. 2014; 6(1):5159. https://doi.org/10.4081/hr.2014.5159

Chicago/Turabian Style

Butler, Matthew J., Ming Yin, and Fahd Quddus. 2014. "Isolated Hemolytic Anemia: An Unusual Manifestation of Occult Malignancy" Hematology Reports 6, no. 1: 5159. https://doi.org/10.4081/hr.2014.5159

APA Style

Butler, M. J., Yin, M., & Quddus, F. (2014). Isolated Hemolytic Anemia: An Unusual Manifestation of Occult Malignancy. Hematology Reports, 6(1), 5159. https://doi.org/10.4081/hr.2014.5159

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