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Case Report

Acute Liver Failure as the First Manifestation of Very Late Relapsing of Hodgkin’s Disease

1
Servicio de Hematología, Hospital de Tortosa Verge de la Cinta, C/Esplanetes s/n, 43500 Tortosa, Spain
2
Servicio de Anatomía Patológica, Hospital de Tortosa Verge de la Cinta, 43500 Tortosa, Spain
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2010, 2(1), e5; https://doi.org/10.4081/hr.2010.e5
Submission received: 25 March 2010 / Revised: 15 July 2010 / Accepted: 15 July 2010 / Published: 23 July 2010

Abstract

Hodgkin’s disease is, in general, a lymph node-based disease. It usually starts in an area within the lymphatic system and spreads, in an orderly manner, along the lymph­atic chain to contiguous lymph node areas. There have been sporadic case reports of acute liver failure caused by hematological malignancies. Generally, liver failure is a feature of stage IV end-stage disease, when it occurs in lymphoma. Thus, hepatic involvement usually occurs late in the course of Hodgkin’s disease or with advanced-stage disease, and primary presentation in the liver with acute liver failure is extremely rare. In most cases, the diagnosis was made at aut­opsy. We describe a patient with Hodgkin’s disease presenting with acute liver failure. This is a very unusual Hodgkin’s disease form of presentation, because the acute liver failure was the presenting feature of the disease. Furthermore, the lymphoma occurred as a very late relapse, twenty years after the first diagnosis. To the best of our knowledge, such a case has not been described to date.
Keywords: cute liver failure, Hodgkin’s diseas cute liver failure, Hodgkin’s diseas

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MDPI and ACS Style

Ortín, X.; Rodríguez-Luaces, M.; Bosch, R.; Lejeune, M.; Font, L. Acute Liver Failure as the First Manifestation of Very Late Relapsing of Hodgkin’s Disease. Hematol. Rep. 2010, 2, e5. https://doi.org/10.4081/hr.2010.e5

AMA Style

Ortín X, Rodríguez-Luaces M, Bosch R, Lejeune M, Font L. Acute Liver Failure as the First Manifestation of Very Late Relapsing of Hodgkin’s Disease. Hematology Reports. 2010; 2(1):e5. https://doi.org/10.4081/hr.2010.e5

Chicago/Turabian Style

Ortín, Xavier, Marta Rodríguez-Luaces, Ramon Bosch, Marylene Lejeune, and Llorenç Font. 2010. "Acute Liver Failure as the First Manifestation of Very Late Relapsing of Hodgkin’s Disease" Hematology Reports 2, no. 1: e5. https://doi.org/10.4081/hr.2010.e5

APA Style

Ortín, X., Rodríguez-Luaces, M., Bosch, R., Lejeune, M., & Font, L. (2010). Acute Liver Failure as the First Manifestation of Very Late Relapsing of Hodgkin’s Disease. Hematology Reports, 2(1), e5. https://doi.org/10.4081/hr.2010.e5

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