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Hematology Reports
Volume 11
Issue 3
10.4081/hr.2019.7946
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Article

Magnetic Resonance Imaging of Changes in the Brain of Children Cured of Acute Lymphoblastic Leukemia

by
Vladislav P. Bondarenko
1,2,*,
Galina V. Tereschenko
1,
Mikhail M. Andrianov
1,
Yulia V. Rumyantseva
1,
Alexander I. Karachunsky
1,
Vladimir N. Kasatkin
1,
Alexander F. Karelin
1,
Viktor N. Anisimov
1,3,
Elena V. Zhukovskaya
1 and
Alexander G. Rumyantsev
1
1
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare, 1 Samory Mashela Str., 117997 Moscow, Russia
2
Clinical Hospital 17, 117638 Moscow, Russia
3
Lomonosov Moscow State University, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2019, 11(3), 7946; https://doi.org/10.4081/hr.2019.7946
Submission received: 6 December 2018 / Revised: 16 April 2019 / Accepted: 5 July 2010 / Published: 18 September 2019

Abstract

This study was aimed to systematize magnetic resonance imaging (MRI) presentation of toxic leukoencephalopathy, to find the correlation between method of central nervous system (CNS) leukemia prevention and changes on MRI, to find relationship between existence leukoencephalopathy on imaging and neurocognitive deficits in pediatric patients after anti-leukemic therapy. Brain MRI data of 48 children, who underwent a therapy course according to the ALL-MB intermediate risk protocol, was evaluated. In accordance with two arms of this protocol, they received either radiation therapy, or additional intrathecal administration of chemotherapeutic agents as a prevention of CNS leukemia. Also, neurocognitive tests were performed. According to the results of the performed investigation, 10 (50%) out of 20 children, who received cranial irradiation and 18 (66.6%) out of 27 patients, who received only intrathecal therapy demonstrated abnormal brain changes (leukoencephalopathy) according to MRI data. Leukoencephalopathy was mostly presented by diffuse zones and localized predominantly in the frontal and temporal lobes. There was no correlation between method of CNS prevention and the existence of leukoencephalopathy on MRI. The analysis of our data did not show significant differences in brain damage and severity of cognitive impairment depending on the type of prevention of CNS leukemia. Moreover, in this study no statistical correlation was found between leukoencephalopathy on MRI and neurocognitive impairment according to clinical tests data. Further long-term prospective studies and examinations should be performed to assess late neurotoxic effects.
Keywords: magnetic resonance imaging; acute lymphoblastic leukemia; neuroimaging; neurotoxicity; rehabilitation magnetic resonance imaging; acute lymphoblastic leukemia; neuroimaging; neurotoxicity; rehabilitation

Share and Cite

MDPI and ACS Style

Bondarenko, V.P.; Tereschenko, G.V.; Andrianov, M.M.; Rumyantseva, Y.V.; Karachunsky, A.I.; Kasatkin, V.N.; Karelin, A.F.; Anisimov, V.N.; Zhukovskaya, E.V.; Rumyantsev, A.G. Magnetic Resonance Imaging of Changes in the Brain of Children Cured of Acute Lymphoblastic Leukemia. Hematol. Rep. 2019, 11, 7946. https://doi.org/10.4081/hr.2019.7946

AMA Style

Bondarenko VP, Tereschenko GV, Andrianov MM, Rumyantseva YV, Karachunsky AI, Kasatkin VN, Karelin AF, Anisimov VN, Zhukovskaya EV, Rumyantsev AG. Magnetic Resonance Imaging of Changes in the Brain of Children Cured of Acute Lymphoblastic Leukemia. Hematology Reports. 2019; 11(3):7946. https://doi.org/10.4081/hr.2019.7946

Chicago/Turabian Style

Bondarenko, Vladislav P., Galina V. Tereschenko, Mikhail M. Andrianov, Yulia V. Rumyantseva, Alexander I. Karachunsky, Vladimir N. Kasatkin, Alexander F. Karelin, Viktor N. Anisimov, Elena V. Zhukovskaya, and Alexander G. Rumyantsev. 2019. "Magnetic Resonance Imaging of Changes in the Brain of Children Cured of Acute Lymphoblastic Leukemia" Hematology Reports 11, no. 3: 7946. https://doi.org/10.4081/hr.2019.7946

APA Style

Bondarenko, V. P., Tereschenko, G. V., Andrianov, M. M., Rumyantseva, Y. V., Karachunsky, A. I., Kasatkin, V. N., Karelin, A. F., Anisimov, V. N., Zhukovskaya, E. V., & Rumyantsev, A. G. (2019). Magnetic Resonance Imaging of Changes in the Brain of Children Cured of Acute Lymphoblastic Leukemia. Hematology Reports, 11(3), 7946. https://doi.org/10.4081/hr.2019.7946

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