Use of Catridecacog in a Patient with Severe Factor XIII Deficiency Undergoing Surgery

Gianluca Sottilotta; Francesca Luise; Vincenzo Oriana; Angela Piromalli; Rosa Santacroce; Alessandra Di Lelio

doi:10.4081/hr.2019.7912

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Case Report

19 February 2019

Use of Catridecacog in a Patient with Severe Factor XIII Deficiency Undergoing Surgery

and

UOSD Microcitemie—Centro Emofilia—Servizio Emostasi e Trombosi, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, 89124 Reggio Calabria, Italy

Servizio di Genetica Medica, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Foggia, 71122 Foggia, Italy

Center for Outcomes Research and Clinical Epidemiology—CORESEARCH, Via Tiziano Vecellio 2, 65124 Pescara, Italy

Author to whom correspondence should be addressed.

Hematol. Rep.2019, 11(1), 7912;https://doi.org/10.4081/hr.2019.7912

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Abstract

Despite many articles regarding the antihemorrhagic treatment and prophylaxis, there is a lack of experience about how to best conduct major surgical procedures in patients with congenital factor XIII (FXIII) deficiency. Here we report a case of surgery (right inguinal hernia, complicated by heaviness and pain) performed in a patient with FXIII deficiency, receiving recombinant FXIII prophylaxis (Catridecacog 35 UI/kg every 28 ± 2 days). Our experience shows that Catridecacog can be used safely and effectively not only for continued prophylaxis but also in surgery and adds to the very limited body of evidence currently available on surgery in this bleeding disorder.

Keywords:

recombinant FXIII; congenital FXIII deficiency; surgery

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