Infectious Disease Reports, Volume 15, Issue 6
2023 December - 12 articles
Cover Story: Drug-induced liver injury secondary to ATT treatment (TB-DILI) is reported in 2–28% of patients, varying with the definition, study sample, and treatment regimen. Here, we describe a retrospective descriptive case-series study, including a total of 10 patients who underwent liver biopsy in the course of TB-DILI. The histopathological diagnosis revealed liver injury due to DILI in 5/10 (50%) cases. In one case, a liver biopsy showed necrotizing granulomatous hepatitis. Severe and persistent elevations of liver transaminases and or hepatic cholestasis despite discontinuation of therapy and other suspected liver-related conditions were the indications of liver biopsy, which remains a valuable tool in the evaluation of selected patients with TB-DILI. The decision to perform a liver biopsy should be based on clinical judgment, considering the benefits and risks of the procedure. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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