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Infectious Disease Reports, Volume 16, Issue 1

2024 February - 10 articles

Cover Story: Cytomegalovirus (CMV) infections are challenging in immunocompromised patients. Until recently, anti-CMV drugs such as (val)ganciclovir (GCV), foscarnet (FOS) and cidofovir (CDV) were all viral DNA polymerase inhibitors. However, these drugs may induce cross-resistance and cause serious side-effects. In 2017, letermovir (LMV) was approved for the prophylaxis of CMV infection in CMV-seropositive adults who received an allogeneic hematopoietic stem cell transplant. Maribavir (MBV) was approved in 2021 for the treatment of adult transplant patients with refractory/resistant CMV disease. LMV targets the CMV terminase complex and prevents viral DNA cleavage and its packaging into capsids. MBV inhibits the pUL97 kinase and interferes with virion maturation. This review provides an update on these novel antiviral drugs for the prevention and treatment of CMV infections in transplant recipients. View this paper
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Articles (10)

  • Article
  • Open Access
9 Citations
4,172 Views
14 Pages

Respiratory Syncytial Virus (RSV) and Intention to Recommend RSV Vaccination: A Cross-Sectional Survey of Cardiologists and Cardiac Nurses in Southern Italy

  • Domenico Ponticelli,
  • Lorenzo Losa,
  • Ippazio Cosimo Antonazzo,
  • Anna Zampella,
  • Fabio Di Marino,
  • Gaetano Mottola,
  • Mara Noemi Fede,
  • Fortuna Gallucci,
  • Roberto Magliuolo and
  • Pietro Ferrara
  • + 3 authors

15 February 2024

As respiratory syncytial virus (RSV) vaccine distribution gains traction in Europe and Italy, healthcare workers (HCWs) can strategize about vaccine promotion to increase uptake among patients at risk of RSV consequences, such cardiac patients. This...

(This article belongs to the Section Viral Infections)
  • Article
  • Open Access
11 Citations
2,864 Views
12 Pages

Impact of the COVID-19 Pandemic Surveillance of Visceral Leishmaniasis in Brazil: An Ecological Study

  • Josefa Rayane Santos Silveira,
  • Shirley Verônica Melo Almeida Lima,
  • Allan Dantas dos Santos,
  • Luana Silva Siqueira,
  • Guilherme Reis de Santana Santos,
  • Álvaro Francisco Lopes de Sousa,
  • Layze Braz de Oliveira,
  • Isabel Amélia Costa Mendes and
  • Caíque Jordan Nunes Ribeiro

9 February 2024

The aim of the study was to assess the impact of the COVID-19 pandemic on the notification of new VL cases in Brazil in 2020. It is an ecological and time-series study (2015–2020) with spatial analysis techniques, whose units of analysis were t...

  • Article
  • Open Access
2,633 Views
11 Pages

A Simple Risk Formula for the Prediction of COVID-19 Hospital Mortality

  • Jiří Plášek,
  • Jozef Dodulík,
  • Petr Gai,
  • Barbora Hrstková,
  • Jan Škrha,
  • Lukáš Zlatohlávek,
  • Renata Vlasáková,
  • Peter Danko,
  • Petr Ondráček and
  • Jan Václavík
  • + 4 authors

29 January 2024

SARS-CoV-2 respiratory infection is associated with significant morbidity and mortality in hospitalized patients. We aimed to assess the risk factors for hospital mortality in non-vaccinated patients during the 2021 spring wave in the Czech Republic....

(This article belongs to the Topic Post COVID-19: Latest Advances, Challenges and Methodologies)
  • Review
  • Open Access
3 Citations
4,737 Views
12 Pages

The Subcutaneous Administration of Beta-Lactams: A Case Report and Literary Review—To Do Small Things in a Great Way

  • Gabriele Maria Leanza,
  • Beatrice Liguoro,
  • Simone Giuliano,
  • Chiara Moreal,
  • Luca Montanari,
  • Jacopo Angelini,
  • Tommaso Cai,
  • Rita Murri and
  • Carlo Tascini

29 January 2024

The subcutaneous (s.c.) route is a commonly used method for delivering various drugs, although its application in the administration of antibiotics is relatively uncommon. In this case, we report a successful treatment of nosocomial pneumonia using p...

(This article belongs to the Section Bacterial Diseases)
  • Brief Report
  • Open Access
7 Citations
6,013 Views
10 Pages

Characterization of Lophomonas spp. Infection in a Population of Critical Care Patients

  • Francisco das Neves Coelho,
  • João Borralho,
  • Teresa Baptista-Fernandes,
  • Cristina Toscano and
  • Maria Eduarda Carmo

26 January 2024

Lophomonas are flagellated protozoa that have been increasingly associated with upper and lower airway infection in humans. The prevalence and characterization of this disease in the critically ill remains poorly understood. We present a series of el...

(This article belongs to the Section Parasitological Diseases)
  • Review
  • Open Access
24 Citations
8,075 Views
18 Pages

18 January 2024

Cytomegalovirus (CMV) infections may increase morbidity and mortality in immunocompromised patients. Until recently, standard antiviral drugs against CMV were limited to viral DNA polymerase inhibitors (val)ganciclovir, foscarnet and cidofovir with a...

(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Infectious Diseases)
  • Article
  • Open Access
8 Citations
5,812 Views
30 Pages

10 January 2024

A model of epidemic dynamics is developed that incorporates continuous variables for infection age and vaccination age. The model analyzes pre-symptomatic and symptomatic periods of an infected individual in terms of infection age. This property is s...

  • Brief Report
  • Open Access
2,592 Views
9 Pages

Effect of Different Approaches to Antimicrobial Therapy with Cefmetazole and Meropenem on the Time to Defervescence in Non-Severe Extended-Spectrum β-Lactamase-Producing Escherichia coli Bacteremia

  • Takanobu Hoshi,
  • Satoshi Fujii,
  • Kei Watanabe,
  • Yuta Fukumura,
  • Koji Miyazaki,
  • Madoka Takahashi,
  • Sakae Taniguchi,
  • Shingo Kimura,
  • Arisa Saito and
  • Hideki Sato
  • + 5 authors

27 December 2023

Carbapenems are antimicrobial agents commonly used to treat extended-spectrum β-lactamase (ESBL)-producing bacteria. Although cefmetazole (CMZ) is considered effective for ESBL-producing Escherichia coli (ESBL-EC) bacteremia, previous studies sh...

(This article belongs to the Section Antimicrobial Stewardship and Resistance)
  • Article
  • Open Access
5 Citations
4,223 Views
13 Pages

Urea/Creatinine Ratio’s Correlation with Creatine Kinase Normalization in Pediatric COVID-19 Patients with Myositis: Evaluating Prognostic and Predictive Value

  • Francesco Pizzo,
  • Andrea Marino,
  • Alessandra Di Nora,
  • Serena Spampinato,
  • Giovanni Cacciaguerra,
  • Giuseppe Costanza,
  • Federica Scarlata,
  • Arturo Biasco,
  • Maria Chiara Consentino and
  • Piero Pavone
  • + 4 authors

25 December 2023

Coronavirus disease 2019 (COVID-19) has been chiefly linked with substantial respiratory complications. However, emerging studies have brought attention to the occurrence of severe muscle inflammation (myositis) related to COVID-19, potentially leadi...

(This article belongs to the Section Viral Infections)
  • Article
  • Open Access
6 Citations
3,512 Views
12 Pages

Trends and Spatiotemporal Patterns of Avian Influenza Outbreaks in Italy: A Data-Driven Approach

  • Francesco Branda,
  • Sandra Mazzoli,
  • Massimo Pierini and
  • Massimo Ciccozzi

19 December 2023

In recent years, the unprecedented spread of the Avian Influenza Viruses (AIVs) among birds and mammals has caused devastation in animal populations, including poultry, wild birds, and some mammals, damaging farmers’ livelihoods and the food tr...

(This article belongs to the Section Infection Prevention and Control)
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Infect. Dis. Rep. - ISSN 2036-7449