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Article

PLA-Based Electrospun Nanofibrous Mats Towards Application as Antibiotic Carriers: Processing Parameters, Fabrication and Characterization

by
Evi Christodoulou
1,
Anastasia Chondromatidou
1,
Nikolaos D. Bikiaris
2,
Evangelia Balla
1,
Marilena Vlachou
3,
Panagiotis Barmpalexis
2 and
Dimitrios N. Bikiaris
1,*
1
Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
Laboratory of Pharmaceutical Technology, Division of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
3
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 15784 Athens, Greece
*
Author to whom correspondence should be addressed.
Pharmaceutics 2025, 17(5), 589; https://doi.org/10.3390/pharmaceutics17050589
Submission received: 31 March 2025 / Revised: 21 April 2025 / Accepted: 28 April 2025 / Published: 30 April 2025
(This article belongs to the Special Issue Electrospinning in Drug Delivery Applications)

Abstract

Background/Objectives: Polymeric nanofibers are promising platforms for skin treatment applications due to their large surface area and high porosity, which promote enhanced drug delivery. This study aimed to develop and compare poly(lactic acid)-based (PLA) nanofibrous mats, using linear PLA and a star-like PLA-pentaerythritol (PLA-PE) copolymer, as carriers for transdermal delivery of the antibacterial agent levofloxacin (LEV). Methods: Electrospinning was employed to fabricate nanofibers from PLA and PLA-PE solutions. Spinning parameters and polymer concentrations (10% w/v PLA and 20% w/v PLA-PE) were optimized to produce uniform fibers. LEV was loaded at 10% and 20% w/w. A sum of complementary characterization techniques, including scanning electron microscopy (SEM), infrared spectroscopy (FTIR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC), were applied to comparatively investigate the fibers’ morphology, structural properties, and crystallinity. Drug loading, porosity, degradation, and in vitro release profiles were evaluated. Results: PLA-PE nanofibers demonstrated smaller diameters and higher porosity (up to 90.1%) compared to PLA (82.4%), leading to enhanced drug loading (up to 34.78%) and faster degradation (55% vs. 43% mass loss over 60 days). Drug release exhibited a biphasic profile with an initial burst followed by sustained release. PLA-PE formulations released up to 60.2% LEV, compared to 38.1% for PLA counterparts. Conclusions: The star-like PLA-PE copolymer enhances nanofiber properties relevant to the desired application, including porosity, degradation rate, and drug release. These findings suggest that PLA-PE is a promising material for developing advanced transdermal antibiotic delivery systems.
Keywords: polymeric nanofibers; electrospinning; poly(lactic acid) (PLA); pentaerythritol; transdermal drug delivery; levofloxacin (LEV); antibiotic carriers polymeric nanofibers; electrospinning; poly(lactic acid) (PLA); pentaerythritol; transdermal drug delivery; levofloxacin (LEV); antibiotic carriers
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MDPI and ACS Style

Christodoulou, E.; Chondromatidou, A.; Bikiaris, N.D.; Balla, E.; Vlachou, M.; Barmpalexis, P.; Bikiaris, D.N. PLA-Based Electrospun Nanofibrous Mats Towards Application as Antibiotic Carriers: Processing Parameters, Fabrication and Characterization. Pharmaceutics 2025, 17, 589. https://doi.org/10.3390/pharmaceutics17050589

AMA Style

Christodoulou E, Chondromatidou A, Bikiaris ND, Balla E, Vlachou M, Barmpalexis P, Bikiaris DN. PLA-Based Electrospun Nanofibrous Mats Towards Application as Antibiotic Carriers: Processing Parameters, Fabrication and Characterization. Pharmaceutics. 2025; 17(5):589. https://doi.org/10.3390/pharmaceutics17050589

Chicago/Turabian Style

Christodoulou, Evi, Anastasia Chondromatidou, Nikolaos D. Bikiaris, Evangelia Balla, Marilena Vlachou, Panagiotis Barmpalexis, and Dimitrios N. Bikiaris. 2025. "PLA-Based Electrospun Nanofibrous Mats Towards Application as Antibiotic Carriers: Processing Parameters, Fabrication and Characterization" Pharmaceutics 17, no. 5: 589. https://doi.org/10.3390/pharmaceutics17050589

APA Style

Christodoulou, E., Chondromatidou, A., Bikiaris, N. D., Balla, E., Vlachou, M., Barmpalexis, P., & Bikiaris, D. N. (2025). PLA-Based Electrospun Nanofibrous Mats Towards Application as Antibiotic Carriers: Processing Parameters, Fabrication and Characterization. Pharmaceutics, 17(5), 589. https://doi.org/10.3390/pharmaceutics17050589

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