Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Levofloxacin Mono Hydrate (LV1.0)
2.3. Microscopic IR Spectroscopy Measurements
2.4. Separation of LVODT and LVT Formulations by Particle Size
2.5. Thermal Analyses
2.6. PXRD
2.7. Microscopic Raman Spectroscopy (Conventional and LF)
3. Results and Discussion
3.1. Visual Evaluation of LVODT and LVT Formulations by Microscopic IR Spectroscopy
3.2. DSC and TG-DTA Measurements in Lightly Crushed LVODT and LVT Formulations
3.3. PXRD of the LVODT and LVT Formulations
3.4. Visual Evaluation of LVODT and LVT Formulations by Conventional and LF Raman Microspectroscopy
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Formulations | Non-APIs * |
---|---|
LVODT | MCC ** Carmellose sodium, Hydroxypropyl cellulose, Sucralose, Aminoalkyl methacrylate copolymer E, Talc, Titanium dioxide, Yellow ferric oxide, D-Mannitol, MCC **, Light anhydrous silicic acid, Fragrance, Magnesium stearate, other 3 components |
LVT_CRAVIT | MCC **, Carmellose, Hydroxypropyl cellulose, Stearyl sodium fumarate, Hypromellose, Titanium dioxide, Talc, Macrogol 6000, Yellow ferric oxide, Carnauba wax |
LVT_NIPRO | MCC **, Hydroxypropyl cellulose, Carmellose, Stearyl sodium fumarate, Hypromellose, Macrogol, Talc, Titanium dioxide, Yellow ferric oxide, Carnauba wax |
LVT_SAWAI | Carnauba wax, Carmellose, MCC **, Titanium dioxide, Ferric oxide, Talc, Hydroxypropyl cellulose, Hypromellose, Stearyl sodium fumarate, Macrogol 6000 |
LVT_TOWA | MCC **, Carmellose, Hydroxypropyl cellulose, Cros-carmellose sodium, Magnesium stearate, Hypromellose, Macrogol 6000, Talc, Titanium dioxide, Yellow ferric oxide |
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Yamamoto, Y.; Kajita, M.; Hirose, Y.; Shimada, N.; Fukami, T.; Koide, T. Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy. Pharmaceutics 2023, 15, 2041. https://doi.org/10.3390/pharmaceutics15082041
Yamamoto Y, Kajita M, Hirose Y, Shimada N, Fukami T, Koide T. Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy. Pharmaceutics. 2023; 15(8):2041. https://doi.org/10.3390/pharmaceutics15082041
Chicago/Turabian StyleYamamoto, Yoshihisa, Mizuho Kajita, Yutaro Hirose, Naoki Shimada, Toshiro Fukami, and Tatsuo Koide. 2023. "Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy" Pharmaceutics 15, no. 8: 2041. https://doi.org/10.3390/pharmaceutics15082041
APA StyleYamamoto, Y., Kajita, M., Hirose, Y., Shimada, N., Fukami, T., & Koide, T. (2023). Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy. Pharmaceutics, 15(8), 2041. https://doi.org/10.3390/pharmaceutics15082041