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Pharmaceutics
Volume 15
Issue 3
10.3390/pharmaceutics15030730
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Article

Formation of Hydrophilic Nanofibers from Nanostructural Design in the Co-Encapsulation of Celecoxib through Electrospinning

by
Kedi Chu
1,2,†,
Yi Zhu
1,2,†,
Geng Lu
1,2,
Sa Huang
3,
Chuangzan Yang
1,2,
Juying Zheng
1,2,
Junming Chen
1,2,
Junfeng Ban
1,2,4,5,
Huanhuan Jia
3,* and
Zhufen Lu
1,2,4,5,*
1
Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, China
2
The Innovation Team for Integrating Pharmacy with Entrepreneurship, Guangdong Pharmaceutical University, Guangzhou 510006, China
3
Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510663, China
4
Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China
5
Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceutics 2023, 15(3), 730; https://doi.org/10.3390/pharmaceutics15030730
Submission received: 15 January 2023 / Revised: 9 February 2023 / Accepted: 17 February 2023 / Published: 22 February 2023
(This article belongs to the Section Nanomedicine and Nanotechnology)
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Abstract

This study presents a method for a one-step co-encapsulation of PLGA nanoparticles in hydrophilic nanofibers. The aim is to effectively deliver the drug to the lesion site and achieve a longer release time. The celecoxib nanofiber membrane (Cel-NPs-NFs) was prepared by emulsion solvent evaporation and electrospinning with celecoxib as a model drug. By this method, nanodroplets of celecoxib PLGA are entrapped within polymer nanofibers during an electrospinning process. Moreover, Cel-NPs-NFs exhibited good mechanical strength and hydrophilicity, with a cumulative release of 67.74% for seven days, and the cell uptake at 0.5 h was 2.7 times higher than that of pure nanoparticles. Furthermore, pathological sections of the joint exhibited an apparent therapeutic effect on rat OA, and the drug was delivered effectively. According to the results, this solid matrix containing nanodroplets or nanoparticles could use hydrophilic materials as carriers to prolong drug release time.
Keywords: nanoparticle; nanofiber; drug delivery; osteoarthritis nanoparticle; nanofiber; drug delivery; osteoarthritis
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MDPI and ACS Style

Chu, K.; Zhu, Y.; Lu, G.; Huang, S.; Yang, C.; Zheng, J.; Chen, J.; Ban, J.; Jia, H.; Lu, Z. Formation of Hydrophilic Nanofibers from Nanostructural Design in the Co-Encapsulation of Celecoxib through Electrospinning. Pharmaceutics 2023, 15, 730. https://doi.org/10.3390/pharmaceutics15030730

AMA Style

Chu K, Zhu Y, Lu G, Huang S, Yang C, Zheng J, Chen J, Ban J, Jia H, Lu Z. Formation of Hydrophilic Nanofibers from Nanostructural Design in the Co-Encapsulation of Celecoxib through Electrospinning. Pharmaceutics. 2023; 15(3):730. https://doi.org/10.3390/pharmaceutics15030730

Chicago/Turabian Style

Chu, Kedi, Yi Zhu, Geng Lu, Sa Huang, Chuangzan Yang, Juying Zheng, Junming Chen, Junfeng Ban, Huanhuan Jia, and Zhufen Lu. 2023. "Formation of Hydrophilic Nanofibers from Nanostructural Design in the Co-Encapsulation of Celecoxib through Electrospinning" Pharmaceutics 15, no. 3: 730. https://doi.org/10.3390/pharmaceutics15030730

APA Style

Chu, K., Zhu, Y., Lu, G., Huang, S., Yang, C., Zheng, J., Chen, J., Ban, J., Jia, H., & Lu, Z. (2023). Formation of Hydrophilic Nanofibers from Nanostructural Design in the Co-Encapsulation of Celecoxib through Electrospinning. Pharmaceutics, 15(3), 730. https://doi.org/10.3390/pharmaceutics15030730

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