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Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants

CBIOS-Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal
Department of Biomedical Sciences, University of Alcalá, Ctra. Madrid-Barcelona Km. 33.600, Alcalá de Henares, 28871 Madrid, Spain
Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal
Author to whom correspondence should be addressed.
Academic Editors: Beom-Jin Lee and Phuong Ha-Lien Tran
Pharmaceutics 2021, 13(8), 1163;
Received: 22 June 2021 / Revised: 24 July 2021 / Accepted: 26 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue Solubilization and Controlled Release of Poorly Water-Soluble Drugs)
Lipidic implants are valuable controlled delivery systems that present good biocompatibility and are useful for long-lasting therapies. However, these promising systems can present inflexible drug release profiles that limit their performance. Thus, finding new materials to overcome this drawback is crucial. Herein, lipidic implants containing caffeine and poorly soluble salicylic acid and rutin were developed. The inclusion of Gelucire® 50/02, sucrose, and two biobased ionic liquids, [Cho][Phe] and [Cho][Glu], were evaluated as a mean to improve the performance of the systems. The formulation procedure, dye content distribution, drug content, drug release, water content, and lipidic erosion of the developed systems were assessed. AFM analysis of the implants containing ILs was also performed. The results demonstrated that neither Gelucire® 50/02 nor sucrose were suitable tools to improve the drug release profile. In contrast, the ILs proved to be promising materials for multiple reasons; not only did they facilitate the formulation and incorporation of the studied drugs into the implants, but they also allowed a more suitable release profile, with [Cho][Glu] allowing a higher drug release due to its ability to increase surface wrinkling. Hence, this study showcases ILs as multitalented materials in lipid-based drug implants. View Full-Text
Keywords: lipidic implants; caffeine; salicylic acid; rutin; ionic liquids; improved performance lipidic implants; caffeine; salicylic acid; rutin; ionic liquids; improved performance
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MDPI and ACS Style

Júlio, A.; Sultane, A.; Viana, A.S.; Mota, J.P.; Santos de Almeida, T. Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants. Pharmaceutics 2021, 13, 1163.

AMA Style

Júlio A, Sultane A, Viana AS, Mota JP, Santos de Almeida T. Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants. Pharmaceutics. 2021; 13(8):1163.

Chicago/Turabian Style

Júlio, Ana, Anaisa Sultane, Ana S. Viana, Joana P. Mota, and Tânia Santos de Almeida. 2021. "Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants" Pharmaceutics 13, no. 8: 1163.

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