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Review

Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities

1
Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614, USA
2
College of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates
3
Department of Drug Discovery & Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
4
Department of Cancer Biology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43606, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Mireia Mallandrich and Francisco Fernández-Campos
Pharmaceutics 2021, 13(7), 960; https://doi.org/10.3390/pharmaceutics13070960
Received: 17 May 2021 / Revised: 17 June 2021 / Accepted: 22 June 2021 / Published: 26 June 2021
(This article belongs to the Special Issue Drug Delivery and Penetration through Skin and Its Formulations)
Chemotherapeutic drugs are primarily administered to cancer patients via oral or parenteral routes. The use of transdermal drug delivery could potentially be a better alternative to decrease the dose frequency and severity of adverse or toxic effects associated with oral or parenteral administration of chemotherapeutic drugs. The transdermal delivery of drugs has shown to be advantageous for the treatment of highly localized tumors in certain types of breast and skin cancers. In addition, the transdermal route can be used to deliver low-dose chemotherapeutics in a sustained manner. The transdermal route can also be utilized for vaccine design in cancer management, for example, vaccines against cervical cancer. However, the design of transdermal formulations may be challenging in terms of the conjugation chemistry of the molecules and the sustained and reproducible delivery of therapeutically efficacious doses. In this review, we discuss the nano-carrier systems, such as nanoparticles, liposomes, etc., used in recent literature to deliver chemotherapeutic agents. The advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs are summarized. Furthermore, we also discuss a possible in silico approach, Formulating for Efficacy™, to design transdermal formulations that would probably be economical, robust, and more efficacious. View Full-Text
Keywords: chemotherapeutics; melanoma; breast cancer; nanoparticles; liposomes; transdermal vaccine; transdermal delivery chemotherapeutics; melanoma; breast cancer; nanoparticles; liposomes; transdermal vaccine; transdermal delivery
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MDPI and ACS Style

Neupane, R.; Boddu, S.H.S.; Abou-Dahech, M.S.; Bachu, R.D.; Terrero, D.; Babu, R.J.; Tiwari, A.K. Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities. Pharmaceutics 2021, 13, 960. https://doi.org/10.3390/pharmaceutics13070960

AMA Style

Neupane R, Boddu SHS, Abou-Dahech MS, Bachu RD, Terrero D, Babu RJ, Tiwari AK. Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities. Pharmaceutics. 2021; 13(7):960. https://doi.org/10.3390/pharmaceutics13070960

Chicago/Turabian Style

Neupane, Rabin, Sai H. S. Boddu, Mariam Sami Abou-Dahech, Rinda Devi Bachu, David Terrero, R. Jayachandra Babu, and Amit K. Tiwari. 2021. "Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities" Pharmaceutics 13, no. 7: 960. https://doi.org/10.3390/pharmaceutics13070960

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