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Review

Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine

1
Department of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
2
Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramon 182 C, 20014 Donostia-San Sebastian, Spain
3
NanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, 61-614 Poznan, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Dong Keun Han
Pharmaceutics 2021, 13(6), 792; https://doi.org/10.3390/pharmaceutics13060792
Received: 1 May 2021 / Revised: 17 May 2021 / Accepted: 20 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Drug Delivery Systems for Combination Therapy)
The increasing demand for organ replacements in a growing world with an aging population as well as the loss of tissues and organs due to congenital defects, trauma and diseases has resulted in rapidly evolving new approaches for tissue engineering and regenerative medicine (TERM). The extracellular matrix (ECM) is a crucial component in tissues and organs that surrounds and acts as a physical environment for cells. Thus, ECM has become a model guide for the design and fabrication of scaffolds and biomaterials in TERM. However, the fabrication of a tissue/organ replacement or its regeneration is a very complex process and often requires the combination of several strategies such as the development of scaffolds with multiple functionalities and the simultaneous delivery of growth factors, biochemical signals, cells, genes, immunomodulatory agents, and external stimuli. Although the development of multifunctional scaffolds and biomaterials is one of the most studied approaches for TERM, all these strategies can be combined among them to develop novel synergistic approaches for tissue regeneration. In this review we discuss recent advances in which multifunctional scaffolds alone or combined with other strategies have been employed for TERM purposes. View Full-Text
Keywords: tissue engineering and regenerative medicine (TERM); biomaterials; scaffolds; multifunctional materials; combination therapy tissue engineering and regenerative medicine (TERM); biomaterials; scaffolds; multifunctional materials; combination therapy
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MDPI and ACS Style

Muzzio, N.; Moya, S.; Romero, G. Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine. Pharmaceutics 2021, 13, 792. https://doi.org/10.3390/pharmaceutics13060792

AMA Style

Muzzio N, Moya S, Romero G. Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine. Pharmaceutics. 2021; 13(6):792. https://doi.org/10.3390/pharmaceutics13060792

Chicago/Turabian Style

Muzzio, Nicolas, Sergio Moya, and Gabriela Romero. 2021. "Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine" Pharmaceutics 13, no. 6: 792. https://doi.org/10.3390/pharmaceutics13060792

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