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Review

Microfluidic and Lab-on-a-Chip Systems for Cutaneous Wound Healing Studies

1
Institute of Applied Synthetic Chemistry, Faculty of Technical Chemistry, Vienna University of Technology, 1060 Vienna, Austria
2
Karl Chiari Lab for Orthopaedic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, 1090 Vienna, Austria
*
Authors to whom correspondence should be addressed.
Academic Editor: Giuseppe De Rosa
Pharmaceutics 2021, 13(6), 793; https://doi.org/10.3390/pharmaceutics13060793
Received: 26 April 2021 / Revised: 19 May 2021 / Accepted: 24 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Biological Barriers in Health and Disease)
Cutaneous wound healing is a complex, multi-stage process involving direct and indirect cell communication events with the aim of efficiently restoring the barrier function of the skin. One key aspect in cutaneous wound healing is associated with cell movement and migration into the physically, chemically, and biologically injured area, resulting in wound closure. Understanding the conditions under which cell migration is impaired and elucidating the cellular and molecular mechanisms that improve healing dynamics are therefore crucial in devising novel therapeutic strategies to elevate patient suffering, reduce scaring, and eliminate chronic wounds. Following the global trend towards the automation, miniaturization, and integration of cell-based assays into microphysiological systems, conventional wound healing assays such as the scratch assay and cell exclusion assay have recently been translated and improved using microfluidics and lab-on-a-chip technologies. These miniaturized cell analysis systems allow for precise spatial and temporal control over a range of dynamic microenvironmental factors including shear stress, biochemical and oxygen gradients to create more reliable in vitro models that resemble the in vivo microenvironment of a wound more closely on a molecular, cellular, and tissue level. The current review provides (a) an overview on the main molecular and cellular processes that take place during wound healing, (b) a brief introduction into conventional in vitro wound healing assays, and (c) a perspective on future cutaneous and vascular wound healing research using microfluidic technology. View Full-Text
Keywords: cell migration; cutaneous wound healing; wound healing assay; lab-on-a-chip; microfluidics; skin; microvasculature cell migration; cutaneous wound healing; wound healing assay; lab-on-a-chip; microfluidics; skin; microvasculature
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MDPI and ACS Style

Shabestani Monfared, G.; Ertl, P.; Rothbauer, M. Microfluidic and Lab-on-a-Chip Systems for Cutaneous Wound Healing Studies. Pharmaceutics 2021, 13, 793. https://doi.org/10.3390/pharmaceutics13060793

AMA Style

Shabestani Monfared G, Ertl P, Rothbauer M. Microfluidic and Lab-on-a-Chip Systems for Cutaneous Wound Healing Studies. Pharmaceutics. 2021; 13(6):793. https://doi.org/10.3390/pharmaceutics13060793

Chicago/Turabian Style

Shabestani Monfared, Ghazal, Peter Ertl, and Mario Rothbauer. 2021. "Microfluidic and Lab-on-a-Chip Systems for Cutaneous Wound Healing Studies" Pharmaceutics 13, no. 6: 793. https://doi.org/10.3390/pharmaceutics13060793

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