Next Article in Journal
Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis
Previous Article in Journal
Light-Activatable Transfection System Using Hybrid Vectors Composed of Thermosensitive Dendron Lipids and Gold Nanorods
Previous Article in Special Issue
A Solid-in-Oil Nanodispersion System for Transcutaneous Immunotherapy of Cow’s Milk Allergies
Open AccessReview

Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis

1
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka 819-0395, Japan
2
Advanced Transdermal Drug Delivery System Center, Kyushu University, Fukuoka 819-0395, Japan
3
Center for Future Chemistry, Kyushu University, Fukuoka 819-0395, Japan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 240; https://doi.org/10.3390/pharmaceutics12030240
Received: 29 January 2020 / Revised: 3 March 2020 / Accepted: 5 March 2020 / Published: 7 March 2020
(This article belongs to the Special Issue Nanoparticle-Based Drug Delivery Systems for Immunomodulation)
Japanese cedar pollinosis (JCP) is a common affliction caused by an allergic reaction to cedar pollen and is considered a disease of national importance in Japan. Antigen-specific immunotherapy (AIT) is the only available curative treatment for JCP. However, low compliance and persistence have been reported among patients subcutaneously or sublingually administered AIT comprising a conventional antigen derived from a pollen extract. To address these issues, many research studies have focused on developing a safer, simpler, and more effective AIT for JCP. Here, we review the novel antigens that have been developed for JCP AIT, discuss their different administration routes, and present the effects of anti-allergy treatment. Then, we describe a new form of AIT called transcutaneous immunotherapy (TCIT) and its solid-in-oil (S/O) nanodispersion formulation, which is a promising antigen delivery system. Finally, we discuss the applications of S/O nanodispersions for JCP TCIT. In this context, we predict that TCIT delivery by using a S/O nanodispersion loaded with novel antigens may offer an easier, safer, and more effective treatment option for JCP patients. View Full-Text
Keywords: allergen-specific immunotherapy; Japanese cedar pollinosis; solid-in-oil nanodispersions; transcutaneous immunotherapy allergen-specific immunotherapy; Japanese cedar pollinosis; solid-in-oil nanodispersions; transcutaneous immunotherapy
Show Figures

Graphical abstract

MDPI and ACS Style

Kong, Q.; Kitaoka, M.; Wakabayashi, R.; Tahara, Y.; Kamiya, N.; Goto, M. Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis. Pharmaceutics 2020, 12, 240.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop