Next Article in Journal
Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy
Previous Article in Journal
Cell Penetrating Peptides, Novel Vectors for Gene Therapy
Previous Article in Special Issue
Development and In Vivo Evaluation of Multidrug Ultradeformable Vesicles for the Treatment of Skin Inflammation
Open AccessArticle

Cow Milk and Intestinal Epithelial Cell-Derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery

1
School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King’s College London, London SE1 9NH, UK
2
Department of Pharmaceutical and Pharmacological Sciences, Università degli Studi di PADOVA, Via 8 Febbraio, 2, 35122 Padova, Italy
3
School of Life Sciences, University of Lincoln, Lincoln LN6 7TS, UK
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 226; https://doi.org/10.3390/pharmaceutics12030226
Received: 6 February 2020 / Revised: 28 February 2020 / Accepted: 2 March 2020 / Published: 4 March 2020
(This article belongs to the Special Issue Non-Invasive Drug Delivery Systems)
Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility in improving oral drug bioavailability. However, EVs produced by intestinal epithelial cells have not been investigated for this application. We compared the capacity of cow milk EVs and intestinal epithelial cell-derived counterparts to enhance oral drug bioavailability. EVs were isolated, fluorescently labelled, and loaded with curcumin (CUR) as a model poorly absorbable drug. These were then characterised before testing in an intestinal model (Caco-2). Epithelial cell-derived EVs showed notably higher cell uptake compared to cow milk EVs. Cell uptake was significantly higher in differentiated compared to undifferentiated cells for both types of EVs. While both milk- and cell-derived EVs improved the cell uptake and intestinal permeability of CUR (confirming oral drug bioavailability enhancement potential), epithelial cell EVs demonstrated a superior effect. View Full-Text
Keywords: drug absorption; exosomes; extracellular vesicles; intestinal permeability; oral drug bioavailability drug absorption; exosomes; extracellular vesicles; intestinal permeability; oral drug bioavailability
Show Figures

Figure 1

MDPI and ACS Style

Carobolante, G.; Mantaj, J.; Ferrari, E.; Vllasaliu, D. Cow Milk and Intestinal Epithelial Cell-Derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery. Pharmaceutics 2020, 12, 226.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop