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Open AccessArticle

Preparations of Rectal Suppositories Containing Artesunate

School of Pharmacy and Health Sciences, Fairleigh Dickinson University, Florham Park, NJ 07932, USA
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Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 222; https://doi.org/10.3390/pharmaceutics12030222
Received: 30 January 2020 / Revised: 27 February 2020 / Accepted: 28 February 2020 / Published: 2 March 2020
(This article belongs to the Special Issue Paediatric Drug Delivery)
Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas. The main challenges are to improve the solubility of drugs in the rectal fluids and prevent the product from turning rancid or melting in a tropical climate. In this short proof-of-concept study, three types of rectal suppositories of artesunate were prepared: (i) polyethylene glycol (PEG)-based suppositories carrying free artesunate (non-modified artesunate), (ii) PEG-based suppositories carrying artesunate-loaded micelles and (iii) 3D-printed suppositories carrying a PEG/artesunate mixture. Physical parameters of suppositories, release profiles of artesunate (the fastest to the slowest: ii≥i>iii) and thermostability (the most stable to the least stable: iii>ii>i) of suppositories at increased temperature were assessed to determine the advantages and disadvantages of each formulation. View Full-Text
Keywords: artesunate; suppository; micelles; 3D printing artesunate; suppository; micelles; 3D printing
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MDPI and ACS Style

Persaud, S.; Eid, S.; Swiderski, N.; Serris, I.; Cho, H. Preparations of Rectal Suppositories Containing Artesunate. Pharmaceutics 2020, 12, 222.

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