Next Article in Journal
Systematic Investigation of the Effect of Non-Ionic Emulsifiers on Skin by Confocal Raman Spectroscopy—A Comprehensive Lipid Analysis
Next Article in Special Issue
Benefits and Prerequisites Associated with the Adoption of Oral 3D-Printed Medicines for Pediatric Patients: A Focus Group Study among Healthcare Professionals
Previous Article in Journal
Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria
Previous Article in Special Issue
Stability Study of Isoniazid and Rifampicin Oral Solutions Using Hydroxypropyl-Β-Cyclodextrin to Treat Tuberculosis in Paediatrics
Open AccessArticle

Preparations of Rectal Suppositories Containing Artesunate

School of Pharmacy and Health Sciences, Fairleigh Dickinson University, Florham Park, NJ 07932, USA
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 222;
Received: 30 January 2020 / Revised: 27 February 2020 / Accepted: 28 February 2020 / Published: 2 March 2020
(This article belongs to the Special Issue Paediatric Drug Delivery)
Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas. The main challenges are to improve the solubility of drugs in the rectal fluids and prevent the product from turning rancid or melting in a tropical climate. In this short proof-of-concept study, three types of rectal suppositories of artesunate were prepared: (i) polyethylene glycol (PEG)-based suppositories carrying free artesunate (non-modified artesunate), (ii) PEG-based suppositories carrying artesunate-loaded micelles and (iii) 3D-printed suppositories carrying a PEG/artesunate mixture. Physical parameters of suppositories, release profiles of artesunate (the fastest to the slowest: ii≥i>iii) and thermostability (the most stable to the least stable: iii>ii>i) of suppositories at increased temperature were assessed to determine the advantages and disadvantages of each formulation. View Full-Text
Keywords: artesunate; suppository; micelles; 3D printing artesunate; suppository; micelles; 3D printing
Show Figures

Graphical abstract

MDPI and ACS Style

Persaud, S.; Eid, S.; Swiderski, N.; Serris, I.; Cho, H. Preparations of Rectal Suppositories Containing Artesunate. Pharmaceutics 2020, 12, 222.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop