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Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

1
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
2
Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut 71515, Egypt
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Department of Clinical pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
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Department of Pharmaceutics and Industrial Pharmacy, Deraya University, Minia 61768, Egypt
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Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy Sohag University, Sohag 82524, Egypt
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 142; https://doi.org/10.3390/pharmaceutics12020142
Received: 27 December 2019 / Revised: 29 January 2020 / Accepted: 4 February 2020 / Published: 8 February 2020
Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application. View Full-Text
Keywords: nanomedicine; antibacterial resistance; inhibition of antibacterial resistance; anti-biofilm mechanisms; organic nanosystems; inorganic nanosystems nanomedicine; antibacterial resistance; inhibition of antibacterial resistance; anti-biofilm mechanisms; organic nanosystems; inorganic nanosystems
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MDPI and ACS Style

Eleraky, N.E.; Allam, A.; Hassan, S.B.; Omar, M.M. Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations. Pharmaceutics 2020, 12, 142. https://doi.org/10.3390/pharmaceutics12020142

AMA Style

Eleraky NE, Allam A, Hassan SB, Omar MM. Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations. Pharmaceutics. 2020; 12(2):142. https://doi.org/10.3390/pharmaceutics12020142

Chicago/Turabian Style

Eleraky, Nermin E.; Allam, Ayat; Hassan, Sahar B.; Omar, Mahmoud M. 2020. "Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations" Pharmaceutics 12, no. 2: 142. https://doi.org/10.3390/pharmaceutics12020142

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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