Pharmaceutics, Volume 12, Issue 11 (November 2020) – 130 articles
Cover Story (view full-size image):
Extracellular vesicles (EVs) have unique properties that are related to their origin, and these can be exploited for drug delivery applications in cell regeneration, immunomodulation, cancer treatment or cardioprotection. Moreover, their cell-like membrane organization facilitates their uptake and accumulation in specific tissues and organs, which can be exploited to improve the selectivity of cargo delivery. The combination of these properties with the inclusion of drugs or imaging agents can significantly improve therapeutic efficacy and selectivity, reduce undesirable side effects of drugs or permit earlier diagnosis of diseases. We describe the natural properties of EVs that have been isolated from different cell sources and discuss strategies that can be applied to increase their efficacy at specific locations. View this paper.
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