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Liposomal Vitamin D3 as an Anti-aging Agent for the Skin

1,2,†, 3,†, 3, 3,4, 3, 5, 1,6,* and 1,3,6,*
1
Key Laboratory of Effective Components of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China
2
Practice Training Center, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China
3
School of Life Sciences, Jilin University, Changchun 130117, Jilin, China
4
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
5
Department of Clinical Medicine, Norman Bethune Health Science Center of Jilin University, Changchun 130117, Jilin, China
6
Department of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2019, 11(7), 311; https://doi.org/10.3390/pharmaceutics11070311
Received: 8 May 2019 / Revised: 19 June 2019 / Accepted: 20 June 2019 / Published: 3 July 2019
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PDF [1659 KB, uploaded 3 July 2019]
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Abstract

Vitamin D3 is an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier to deliver vitamin D3 to improve the stability and to enhance the treatment effect of vitamin D3. The stability of vitamin D3 liposomes, average cumulative penetration, and retention of vitamin D3 in the skin were then evaluated and compared with free vitamin D3. Finally, the treatment effect of vitamin D3 liposomes in a rat photoaging model was appraised and Haematoxylin-Eosin (H&E) staining was used to assess the histology changes of the skin after vitamin D3 liposome treatment. The results indicated that liposomes could significantly improve the stability of vitamin D3. The average skin retention of vitamin D3 liposomes was 1.65 times that of the vitamin D3 solution. Vitamin D3 liposomes could repair the surface morphology of skin in the photoaging model and promote the production of new collagen fibers. Vitamin D3 liposomes as a potential skin care agent could significantly improve skin appearance and repair damage in the histology of photoaging. View Full-Text
Keywords: vitamin D3; liposomes; prevent photoaging; stability vitamin D3; liposomes; prevent photoaging; stability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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MDPI and ACS Style

Bi, Y.; Xia, H.; Li, L.; Lee, R.J.; Xie, J.; Liu, Z.; Qiu, Z.; Teng, L. Liposomal Vitamin D3 as an Anti-aging Agent for the Skin. Pharmaceutics 2019, 11, 311.

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