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Open AccessCommunication

Re-Epithelialization Appraisal of Skin Wound in a Porcine Model Using a Salmon-Gelatin Based Biomaterial as Wound Dressing

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Centro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile
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Departamento de Física, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile
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Instituto de Biología, Universidad de Valparaíso, Avenida Gran Bretaña 1111, Valparaíso 2340000, Chile
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Biopolymer Research and Engineering Lab, Facultad de Medicina, Universidad de los Andes, Monseñor Álvaro del Portillo 12455, Las Condes, Santiago 7550000, Chile
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(5), 196; https://doi.org/10.3390/pharmaceutics11050196
Received: 21 March 2019 / Revised: 16 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019
The design of new functional materials for skin tissue engineering is an area of constant research. In this work, a novel wound-dressing biomaterial with a porous structure, previously formulated using salmon-gelatin as main component (called salmon-gelatin biomaterial (SGB)), was tested in vivo using pigs as skin wound models. Four weeks after cutaneous excision and implantation in the animals, the healing process did not show apparent symptoms of inflammation or infection. Interestingly, the temporal evolution of wound size from 100% to around 10% would indicate a faster recovery when SGB was compared against a commercial control. Histological analysis established that wounds treated with SGB presented similar healing and epithelialization profiles with respect to the commercial control. Moreover, vascularized granulation tissue and epithelialization stages were clearly identified, indicating a proliferation phase. These results showed that SGB formulation allows cell viability to be maintained. The latter foresees the development of therapeutic alternatives for skin repair based on SGB fabricated using low cost production protocols. View Full-Text
Keywords: wound healing; porcine model; salmon-gelatin biomaterial; in vivo trial wound healing; porcine model; salmon-gelatin biomaterial; in vivo trial
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Acevedo, C.A.; Sánchez, E.; Orellana, N.; Morales, P.; Olguín, Y.; Brown, D.I.; Enrione, J. Re-Epithelialization Appraisal of Skin Wound in a Porcine Model Using a Salmon-Gelatin Based Biomaterial as Wound Dressing. Pharmaceutics 2019, 11, 196.

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