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Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy
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Pharmaceutics 2019, 11(5), 197; https://doi.org/10.3390/pharmaceutics11050197
Received: 20 March 2019 / Revised: 12 April 2019 / Accepted: 22 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue Novel Approaches for Delivery of Anti-HIV Drugs)
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Abstract

An in-depth analysis of nanotechnology applications for the improvement of solubility, distribution, bioavailability and stability of reverse transcriptase inhibitors is reported. Current clinically used nucleoside and non-nucleoside agents, included in combination therapies, were examined in the present survey, as drugs belonging to these classes are the major component of highly active antiretroviral treatments. The inclusion of such agents into supramolecular vesicular systems, such as liposomes, niosomes and lipid solid NPs, overcomes several drawbacks related to the action of these drugs, including drug instability and unfavorable pharmacokinetics. Overall results reported in the literature show that the performances of these drugs could be significantly improved by inclusion into nanosystems. View Full-Text
Keywords: HIV; antiretrovirals; nanoformulations; drug degradation; drug protection HIV; antiretrovirals; nanoformulations; drug degradation; drug protection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Grande, F.; Ioele, G.; Occhiuzzi, M.A.; De Luca, M.; Mazzotta, E.; Ragno, G.; Garofalo, A.; Muzzalupo, R. Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery. Pharmaceutics 2019, 11, 197.

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