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Review

Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy

by 1,2,†, 1,2,†, 1,2, 3,4, 3,4,* and 1,2,5,*
1
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03080, Korea
2
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea
3
Department of Materials Science and Engineering, Korea University, Seoul 02841, Korea
4
Research Institute of Engineering and Technology, Korea University, Seoul 02481, Korea
5
Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul 03080, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2019, 11(10), 493; https://doi.org/10.3390/pharmaceutics11100493
Received: 31 August 2019 / Revised: 18 September 2019 / Accepted: 23 September 2019 / Published: 26 September 2019
(This article belongs to the Special Issue Nanoparticles to Improve the Efficacy of Vaccines)
Engineering and application of nanomaterials have recently helped advance various biomedical fields. Zinc oxide (ZnO)-based nanocomposites have become one of the most promising candidates for biomedical applications due to their biocompatibility, unique physicochemical properties, and cost-effective mass production. In addition, recent advances in nano-engineering technologies enable the generation of ZnO nanocomposites with unique three-dimensional structures and surface characteristics that are optimally designed for in vivo applications. Here, we review recent advances in the application of diverse ZnO nanocomposites, with an especial focus on their development as vaccine adjuvant and cancer immunotherapeutics, as well as their intrinsic properties interacting with the immune system and potential toxic effect in vivo. Finally, we summarize promising proof-of-concept applications as prophylactic and therapeutic vaccines against infections and cancers. Understanding the nano-bio interfaces between ZnO-based nanocomposites and the immune system, together with bio-effective design of the nanomaterial using nano-architectonic technology, may open new avenues in expanding the biomedical application of ZnO nanocomposites as a novel vaccine platform. View Full-Text
Keywords: ZnO nanocomposite; vaccine; cancer; immunotherapy; toxicity; immune cells ZnO nanocomposite; vaccine; cancer; immunotherapy; toxicity; immune cells
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MDPI and ACS Style

Sharma, P.; Jang, N.-Y.; Lee, J.-W.; Park, B.C.; Kim, Y.K.; Cho, N.-H. Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy. Pharmaceutics 2019, 11, 493. https://doi.org/10.3390/pharmaceutics11100493

AMA Style

Sharma P, Jang N-Y, Lee J-W, Park BC, Kim YK, Cho N-H. Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy. Pharmaceutics. 2019; 11(10):493. https://doi.org/10.3390/pharmaceutics11100493

Chicago/Turabian Style

Sharma, Prashant; Jang, Na-Yoon; Lee, Jae-Won; Park, Bum C.; Kim, Young K.; Cho, Nam-Hyuk. 2019. "Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy" Pharmaceutics 11, no. 10: 493. https://doi.org/10.3390/pharmaceutics11100493

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