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Review

The Effects of Synthetically Modified Natural Compounds on ABC Transporters

1
School of Science, Auckland University of Technology, Auckland 1010, New Zealand
2
Translational Genomics Research Institute, Phoenix, AZ 85004, USA
3
AUT-Roche Diagnostics Laboratory, Auckland 1010, New Zealand
4
School of Interprofessional Health Studies, Auckland University of Technology, Auckland 0627, New Zealand
5
College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518061, China
6
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710062, China
7
Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland 1023, New Zealand
8
Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand
*
Author to whom correspondence should be addressed.
Pharmaceutics 2018, 10(3), 127; https://doi.org/10.3390/pharmaceutics10030127
Received: 29 June 2018 / Revised: 3 August 2018 / Accepted: 7 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue ABC Transporter-Mediated Drug Disposition)
Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumulation and thus increase MDR across a variety of cancers. Overcoming MDR is one desired approach to improving the survival rate of patients. To date, a number of modulators have been identified which block the function and/or decrease the expression of ABC transporters, thereby restoring the efficacy of a range of anticancer drugs. However, clinical MDR reversal agents have thus far proven ineffective and/or toxic. The need for new, effective, well-tolerated and nontoxic compounds has led to the development of natural compounds and their derivatives to ameliorate MDR. This review evaluates whether synthetically modifying natural compounds is a viable strategy to generate potent, nontoxic, ABC transporter inhibitors which may potentially reverse MDR. View Full-Text
Keywords: ABC transporter; drug disposition; multidrug resistance; P-glycoprotein (P-gp); breast cancer resistant protein (BCRP); multidrug resistance-associated proteins (MRPs) ABC transporter; drug disposition; multidrug resistance; P-glycoprotein (P-gp); breast cancer resistant protein (BCRP); multidrug resistance-associated proteins (MRPs)
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MDPI and ACS Style

Dantzic, D.; Noel, P.; Merien, F.; Liu, D.-X.; Lu, J.; Han, H.; McKeage, M.J.; Li, Y. The Effects of Synthetically Modified Natural Compounds on ABC Transporters. Pharmaceutics 2018, 10, 127. https://doi.org/10.3390/pharmaceutics10030127

AMA Style

Dantzic D, Noel P, Merien F, Liu D-X, Lu J, Han H, McKeage MJ, Li Y. The Effects of Synthetically Modified Natural Compounds on ABC Transporters. Pharmaceutics. 2018; 10(3):127. https://doi.org/10.3390/pharmaceutics10030127

Chicago/Turabian Style

Dantzic, Daniel, Pawan Noel, Fabrice Merien, Dong-Xu Liu, Jun Lu, Haiyong Han, Mark J. McKeage, and Yan Li. 2018. "The Effects of Synthetically Modified Natural Compounds on ABC Transporters" Pharmaceutics 10, no. 3: 127. https://doi.org/10.3390/pharmaceutics10030127

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