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Pharmaceutics 2018, 10(3), 126; https://doi.org/10.3390/pharmaceutics10030126

Dendrimers Show Promise for siRNA and microRNA Therapeutics

1
Institute of Biophysics and Cell Engineering of NASB, 220072 Minsk, Belarus
2
Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia
3
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), 02972 Seoul, Korea
4
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland
*
Authors to whom correspondence should be addressed.
Received: 24 July 2018 / Revised: 2 August 2018 / Accepted: 3 August 2018 / Published: 8 August 2018
(This article belongs to the Special Issue Dendrimers in Nanomedical Applications: Update and Future Directions)
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Abstract

The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs) is a major problem in molecular biology, biotechnology, and medicine. A relatively new class of highly symmetrical hyperbranched polymers, called dendrimers, shows promise for transporting small TNAs into both cells and target tissues. Dendrimers have intrinsic advantages for this purpose: their physico-chemical and biological properties can be controlled during synthesis, and they are able to transport large numbers of TNA molecules that can specifically suppress the expression of single or multiple targeted genes. Numerous chemical modifications of dendrimers extend the biocompatibility of synthetic materials and allow targeted vectors to be designed for particular therapeutic purposes. This review summarizes the latest experimental data and trends in the medical application of various types of dendrimers and dendrimer-based nanoconstructions as delivery systems for short small interfering RNAs (siRNAs) and microRNAs at the cell and organism levels. It provides an overview of the structural features of dendrimers, indicating their advantages over other types of TNA transporters. View Full-Text
Keywords: dendrimer; denderiplex; dendron; miRNA; siRNA; microRNA; antimiR; gene therapy; gene delivery; gene drugs dendrimer; denderiplex; dendron; miRNA; siRNA; microRNA; antimiR; gene therapy; gene delivery; gene drugs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Dzmitruk, V.; Apartsin, E.; Ihnatsyeu-Kachan, A.; Abashkin, V.; Shcharbin, D.; Bryszewska, M. Dendrimers Show Promise for siRNA and microRNA Therapeutics. Pharmaceutics 2018, 10, 126.

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