Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
AbstractFlaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research. View Full-Text
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Sze, A.; Olagnier, D.; Hadj, S.B.; Han, X.; Tian, X.H.; Xu, H.-T.; Yang, L.; Shi, Q.; Wang, P.; Wainberg, M.A.; Wu, J.H.; Lin, R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses 2017, 9, 287.
Sze A, Olagnier D, Hadj SB, Han X, Tian XH, Xu H-T, Yang L, Shi Q, Wang P, Wainberg MA, Wu JH, Lin R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses. 2017; 9(10):287.Chicago/Turabian Style
Sze, Alexandre; Olagnier, David; Hadj, Samar B.; Han, Xiaoying; Tian, Xiao H.; Xu, Hong-Tao; Yang, Long; Shi, Qingwen; Wang, Penghua; Wainberg, Mark A.; Wu, Jian H.; Lin, Rongtuan. 2017. "Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference." Viruses 9, no. 10: 287.
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