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Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways

Novartis Pharma Germany, Roonstrasse 25, 90429 Nürnberg, Germany
Institute of Virology, Technische Universität München, Trogerstrasse 30, 81675 München, Germany
Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg/München, Germany
Author to whom correspondence should be addressed.
Academic Editor: Matthew D. Weitzman
Viruses 2015, 7(9), 4854-4872;
Received: 6 May 2015 / Revised: 16 August 2015 / Accepted: 20 August 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Viruses and the Ubiquitin/Proteasome System)
Posttranslational modifications (PTMs) of proteins include enzymatic changes by covalent addition of cellular regulatory determinants such as ubiquitin (Ub) and small ubiquitin-like modifier (SUMO) moieties. These modifications are widely used by eukaryotic cells to control the functional repertoire of proteins. Over the last decade, it became apparent that the repertoire of ubiquitiylation and SUMOylation regulating various biological functions is not restricted to eukaryotic cells, but is also a feature of human virus families, used to extensively exploit complex host-cell networks and homeostasis. Intriguingly, besides binding to host SUMO/Ub control proteins and interfering with the respective enzymatic cascade, many viral proteins mimic key regulatory factors to usurp this host machinery and promote efficient viral outcomes. Advanced detection methods and functional studies of ubiquitiylation and SUMOylation during virus-host interplay have revealed that human viruses have evolved a large arsenal of strategies to exploit these specific PTM processes. In this review, we highlight the known viral analogs orchestrating ubiquitin and SUMO conjugation events to subvert and utilize basic enzymatic pathways. View Full-Text
Keywords: SUMO; ubiquitin; virus; analogue; mimicry; SENP; DUB SUMO; ubiquitin; virus; analogue; mimicry; SENP; DUB
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Wimmer, P.; Schreiner, S. Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways. Viruses 2015, 7, 4854-4872.

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