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Open AccessReview

Porcine Bocavirus: Achievements in the Past Five Years

by Feng Zhou 1,†, Haoting Sun 1,† and Yuyan Wang 2,*
1
Department of Clinical Medicine, Huashan Hospital, Fudan University, Shanghai 200032, China
2
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2014, 6(12), 4946-4960; https://doi.org/10.3390/v6124946
Received: 18 August 2014 / Revised: 1 December 2014 / Accepted: 2 December 2014 / Published: 10 December 2014
Porcine bocavirus is a recently discovered virus that infects pigs and is classified within the Bocavirus genus (family Parvoviridae, subfamily Parvovirinae). The viral genome constitutes linear single-stranded DNA and has three open reading frames that encode four proteins: NS1, NP1, VP1, and VP2. There have been more than seven genotypes discovered to date. These genotypes have been classified into three groups based on VP1 sequence. Porcine bocavirus is much more prevalent in piglets that are co-infected with other pathogens than in healthy piglets. The virus can be detected using PCR, loop-mediated isothermal amplification, cell cultures, indirect immunofluorescence, and other molecular virology techniques. Porcine bocavirus has been detected in various samples, including stool, serum, lymph nodes, and tonsils. Because this virus was discovered only five years ago, there are still many unanswered questions that require further research. This review summarizes the current state of knowledge and primary research achievements regarding porcine bocavirus. View Full-Text
Keywords: porcine bocavirus; Parvoviridae; phylogenetic analysis; detection; epidemiology; pathogenesis porcine bocavirus; Parvoviridae; phylogenetic analysis; detection; epidemiology; pathogenesis
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Zhou, F.; Sun, H.; Wang, Y. Porcine Bocavirus: Achievements in the Past Five Years. Viruses 2014, 6, 4946-4960.

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