Feline Foamy Virus-Based Vectors: Advantages of an Authentic Animal Model
Abstract
:1. Introduction
Vector | Virus species | Reference | Characteristics |
---|---|---|---|
SKY4.0 | FFV/HFV | [23] | Hybrid FFV genome with PFV env and bel1/tas replacing the corresponding FFV sequences |
pChatul-2/3 | FFV | [26] | wt FFV-F17 genomic vector driven by the CMV-IE promoter instead of the FFV U3 promoter |
pCF-7 | FFV | [22] | wt FFV-FUV genomic vector driven by the CMV-IE promoter instead of the FFV U3 promoter |
pCF-Bet-Gfp | FFV | [22] | Gfp marker gene expressed as a Bet-Gfp fusion protein or via an IRES element |
pCF-FCVx | FFV/FCV | [4] | Recombinant FFV vaccine vectors expressing FCV capsid epitopes as Bet-FCV-E fusion proteins |
2. Construction of Full-Length and Replication-Competent FFV Genomes
3. Replication-Competent FFV Gene Transfer Vectors
4. Replication-Competent FFV Vaccine Vectors
5. Replication-Deficient FFV Vectors
Vector | Reference | Description |
---|---|---|
pCF-SIN pCF-Bet-Gfp-SIN | [58] | Self-inactivating (SIN) FFV Bet-Gfp vectors |
pCF-7-ubi-lacZ pCF-Δ-ubi-lacZ pCF-SIN-ubi-lacZ | [30] | Env- and bel-deficient FFV vectors expressing the lacZ gene from the ubiC promoter and with intact, truncated or SIN LTR promoters |
pCF-7-ubi-lacZ-mATG pCF-7-ubi-lacZ-mΔBB | [54] | pCF−/−ubi-lacZ-derived vectors with inactivated gag ATG start codon and gag-pol deletions |
pCF-SIN-ubi-egfp | described here | pCF-SIN-ubi-lacZ-derived vectors in which the detrimental lacZ reporter gene was replaced by the neutral egfp gene |
5.1. First-Generation RD FFV Vectors
5.2. Second-Generation RD FFV Vectors
5.3. Third-Generation Gutless FFV Vectors
6. Future Developments
Acknowledgments
Conflict of Interest
References and Notes
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Liu, W.; Lei, J.; Liu, Y.; Lukic, D.S.; Räthe, A.-M.; Bao, Q.; Kehl, T.; Bleiholder, A.; Hechler, T.; Löchelt, M. Feline Foamy Virus-Based Vectors: Advantages of an Authentic Animal Model. Viruses 2013, 5, 1702-1718. https://doi.org/10.3390/v5071702
Liu W, Lei J, Liu Y, Lukic DS, Räthe A-M, Bao Q, Kehl T, Bleiholder A, Hechler T, Löchelt M. Feline Foamy Virus-Based Vectors: Advantages of an Authentic Animal Model. Viruses. 2013; 5(7):1702-1718. https://doi.org/10.3390/v5071702
Chicago/Turabian StyleLiu, Weibin, Janet Lei, Yang Liu, Dragana Slavkovic Lukic, Ann-Mareen Räthe, Qiuying Bao, Timo Kehl, Anne Bleiholder, Torsten Hechler, and Martin Löchelt. 2013. "Feline Foamy Virus-Based Vectors: Advantages of an Authentic Animal Model" Viruses 5, no. 7: 1702-1718. https://doi.org/10.3390/v5071702