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Addendum: Bastos, J.C.S.; Kohn, L.K.; Fantinatti-Garboggini, F.; Padilla, M.A.; Flores, E.F.; da Silva, B.P.; de Menezes, C.B.A.; Arns, C.W. Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus. Viruses 2013, 5, 1219-1230.
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Suppression of Coronavirus Replication by Cyclophilin Inhibitors
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Viruses 2013, 5(7), 1684-1701;

Cyclophilins as Modulators of Viral Replication

Department of Biological Science, The Florida State University, Tallahassee, FL 32306, USA
Author to whom correspondence should be addressed.
Received: 22 May 2013 / Revised: 26 June 2013 / Accepted: 3 July 2013 / Published: 11 July 2013
(This article belongs to the Special Issue Cyclophilins and Viruses)
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Cyclophilins are peptidyl‐prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for cyclophilins to serve as a drug target for antiviral therapy is evidenced by the success of non-immunosuppressive cyclophilin inhibitors (CPIs), including Alisporivir, in clinical trials targeting hepatitis C virus infection. In addition, as cyclophilins are implicated in the predisposition to, or severity of, various diseases, the ability to specifically and effectively modulate their function will prove increasingly useful for disease intervention. In this review, we will summarize the evidence of cyclophilins as key mediators of viral infection and prospective drug targets. View Full-Text
Keywords: cyclosporin; HIV; HCV; cyclophilin cyclosporin; HIV; HCV; cyclophilin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Frausto, S.D.; Lee, E.; Tang, H. Cyclophilins as Modulators of Viral Replication. Viruses 2013, 5, 1684-1701.

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