Next Article in Journal
Hepatitis B and C Viruses and Hepatocellular Carcinoma
Next Article in Special Issue
Molecular Basis for Drug Resistance in HIV-1 Protease
Previous Article in Journal
The Genomic Diversity and Phylogenetic Relationship in the Family Iridoviridae
Previous Article in Special Issue
Role of Gag in HIV Resistance to Protease Inhibitors
Article Menu

Export Article

Open AccessReview
Viruses 2010, 2(7), 1476-1503;

The “Connection” Between HIV Drug Resistance and RNase H

Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Present address: Meso Scale Diagnostics, LLC, Gaithersburg, Maryland 20877, USA.
Author to whom correspondence should be addressed.
Received: 21 June 2010 / Revised: 20 July 2010 / Accepted: 20 July 2010 / Published: 21 July 2010
(This article belongs to the Special Issue HIV Drug Resistance 2010)
Full-Text   |   PDF [481 KB, uploaded 12 May 2015]   |  


Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the polymerase (pol) domain of reverse transcriptase (RT), most genotypic analysis for drug resistance is limited to the first ~300 amino acids of RT. However, recent studies have demonstrated that mutations in the C-terminal domain of RT, specifically the connection subdomain and RNase H domain, can also increase resistance to both NRTIs and NNRTIs. In this review we will present the potential mechanisms by which mutations in the C-terminal domain of RT influence NRTI and NNRTI susceptibility, summarize the prevalence of the mutations in these regions of RT identified to date, and discuss their importance to clinical drug resistance. View Full-Text
Keywords: connection subdomain; NRTI; NNRTI; RNase H; drug resistance; HIV connection subdomain; NRTI; NNRTI; RNase H; drug resistance; HIV

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Delviks-Frankenberry, K.A.; Nikolenko, G.N.; Pathak, V.K. The “Connection” Between HIV Drug Resistance and RNase H. Viruses 2010, 2, 1476-1503.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top