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Article

Efficacy of Unsupervised Self-Collected Mid-Turbinate FLOQSwabs for the Diagnosis of Coronavirus Disease 2019 (COVID-19)

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COVID Laboratory, Biogem Scarl, Via Camporeale, 83031 Ariano Irpino, Italy
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Protein Factory, Biogem Scarl, Via Camporeale, 83031 Ariano Irpino, Italy
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Molecular Oncology and Precision Medicine Laboratory, Biogem Scarl, Via Camporeale, 83031 Ariano Irpino, Italy
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Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
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Infectious and Tropical Diseases Division, AORN “Sant’Anna and San Sebastiano”, 81100 Caserta, Italy
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Respiratory Diseases Division, AORN “Sant’Anna and San Sebastiano”, 81100 Caserta, Italy
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Testami SRL, 80122 Naples, Italy
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Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
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Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
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“S.Ottone Frangipane” Hospital, 83031 Ariano Irpino, Italy
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Translational Nephrology, Biogem Scarl, Via Camporeale, 83031 Ariano Irpino, Italy
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Global Scientific Affairs Director at COPAN ITALIA spa Via F. Perotti 10, 25125 Brescia, Italy
*
Authors to whom correspondence should be addressed.
These authors have equally contributed to the manuscript.
Academic Editors: Bertram Flehmig and Karin Klingel
Viruses 2021, 13(8), 1663; https://doi.org/10.3390/v13081663
Received: 21 May 2021 / Revised: 2 August 2021 / Accepted: 17 August 2021 / Published: 22 August 2021
(This article belongs to the Special Issue Viral Markers and the Diagnosis of COVID-19)
Context: The Global Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic has resulted in explosive patterns of transmission in most countries. Nasopharyngeal swabs were the specimen’s collection tools recommended for the diagnosis of SARS-CoV-2 infection, and for monitoring infection outbreaks in communities. Our objective was to report the quality and efficacy of unsupervised self-collected mid turbinate “dry FLOQSwabs” (MT FLOQSwabs) (56380CS01, Copan). There were 111 specimens collected for the study: 36 by health care personnel, from themselves, to verify the quality and efficacy of mid-turbinate swabs; 75 to compare and assess the diagnostic performance, among health care personnel, of nasopharyngeal swabs and self-collected mid-turbinate FLOQSwabs. A collection of 51 specimens was enrolled to define the efficacy of the Testami program (validation). Our analyses demonstrate that self-collected mid-turbinate dry swabs ensure an accuracy of 97.3%, as compared to the standard nasopharyngeal swabs collected by health care workers. Furthermore, the mid-turbinate FLOQSwabs can be stored without medium for six days at room temperature without affecting the molecular diagnosis of the SARS-CoV-2 virus infection. Self-collection of diagnostic specimens at home could offer an avenue to increase testing availability for SARS-CoV-2 infection without asking people to travel to a clinic or a laboratory, thus reducing people’s exposure to infection. Our findings demonstrate that unsupervised self-collection swabs, transported dry, are sensitive, practical and easy-to-use tools and should be considered for diagnosis of SARS-COV-2 and coronavirus disease 2019 (COVID-19) surveillance. View Full-Text
Keywords: SARS-CoV-2; surveillance; dry swab; unsupervised self-collection SARS-CoV-2; surveillance; dry swab; unsupervised self-collection
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MDPI and ACS Style

D’Andrea, E.L.; Cossu, A.M.; Scrima, M.; Messina, V.; Iuliano, P.; Di Perna, F.; Pizza, M.; Pizza, F.; Coppola, N.; Rinaldi, L.; Bellizzi, A.M.; Pelosi, C.; Cocca, C.; Frieri, A.; Lo Calzo, F.; Capasso, G.; Castriciano, S.; Maggi, P.; Fucci, A.; Caraglia, M. Efficacy of Unsupervised Self-Collected Mid-Turbinate FLOQSwabs for the Diagnosis of Coronavirus Disease 2019 (COVID-19). Viruses 2021, 13, 1663. https://doi.org/10.3390/v13081663

AMA Style

D’Andrea EL, Cossu AM, Scrima M, Messina V, Iuliano P, Di Perna F, Pizza M, Pizza F, Coppola N, Rinaldi L, Bellizzi AM, Pelosi C, Cocca C, Frieri A, Lo Calzo F, Capasso G, Castriciano S, Maggi P, Fucci A, Caraglia M. Efficacy of Unsupervised Self-Collected Mid-Turbinate FLOQSwabs for the Diagnosis of Coronavirus Disease 2019 (COVID-19). Viruses. 2021; 13(8):1663. https://doi.org/10.3390/v13081663

Chicago/Turabian Style

D’Andrea, Egildo L., Alessia M. Cossu, Marianna Scrima, Vincenzo Messina, Pasquale Iuliano, Felice Di Perna, Marco Pizza, Fabio Pizza, Nicola Coppola, Luca Rinaldi, Anna M. Bellizzi, Chiara Pelosi, Carmen Cocca, Angelo Frieri, Fabio Lo Calzo, Giovambattista Capasso, Santina Castriciano, Paolo Maggi, Alessandra Fucci, and Michele Caraglia. 2021. "Efficacy of Unsupervised Self-Collected Mid-Turbinate FLOQSwabs for the Diagnosis of Coronavirus Disease 2019 (COVID-19)" Viruses 13, no. 8: 1663. https://doi.org/10.3390/v13081663

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