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Article

Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia

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Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia
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Medical Research Center, Jazan University, Jazan 45142, Saudi Arabia
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Department of Community Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Ministry of Health, Jeddah 23325, Saudi Arabia
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Department of Oral and Maxillofacial Surgery, King Fahad General Hospital, Jeddah 23325, Saudi Arabia
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Department of Phlebotomy, Blood Bank & Laboratory, King Fahad General Hospital, Jeddah 23325, Saudi Arabia
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Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Medical Laboratory Technology, University of Tabuk, Tabuk 71491, Saudi Arabia
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College of Applied Medical Sciences, Taibah University, Almadinah Almunwarah 42353, Saudi Arabia
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Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Author to whom correspondence should be addressed.
Academic Editor: Dimitrios Paraskevis
Viruses 2021, 13(7), 1413; https://doi.org/10.3390/v13071413
Received: 7 June 2021 / Revised: 8 July 2021 / Accepted: 19 July 2021 / Published: 20 July 2021
(This article belongs to the Topic Burden of COVID-19 in Different Countries)
Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy. View Full-Text
Keywords: SARS-CoV-2; COVID-19 pandemic; anti-S Abs; seroprevalence; Jeddah; HCWs SARS-CoV-2; COVID-19 pandemic; anti-S Abs; seroprevalence; Jeddah; HCWs
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MDPI and ACS Style

Alhabbab, R.Y.; Alsaieedi, A.; Algaissi, A.; Almahboub, S.; Al-Raddadi, R.M.; Shabouni, O.I.; Alhabbab, R.; Alfaraj, A.A.; Alamri, S.S.; Aljehani, N.D.; Abdulal, R.H.; Alfaleh, M.A.; Abujamel, T.S.; Alkayyal, A.A.; Mahmoud, A.B.; Abuzenadah, A.M.; Hashem, A.M. Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia. Viruses 2021, 13, 1413. https://doi.org/10.3390/v13071413

AMA Style

Alhabbab RY, Alsaieedi A, Algaissi A, Almahboub S, Al-Raddadi RM, Shabouni OI, Alhabbab R, Alfaraj AA, Alamri SS, Aljehani ND, Abdulal RH, Alfaleh MA, Abujamel TS, Alkayyal AA, Mahmoud AB, Abuzenadah AM, Hashem AM. Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia. Viruses. 2021; 13(7):1413. https://doi.org/10.3390/v13071413

Chicago/Turabian Style

Alhabbab, Rowa Y., Ahdab Alsaieedi, Abdullah Algaissi, Sara Almahboub, Rajaa M. Al-Raddadi, Omaima I. Shabouni, Rahaf Alhabbab, Abdulelah A. Alfaraj, Sawsan S. Alamri, Najwa D. Aljehani, Rwaa H. Abdulal, Mohamed A. Alfaleh, Turki S. Abujamel, Almohanad A. Alkayyal, Ahmad B. Mahmoud, Adel M. Abuzenadah, and Anwar M. Hashem 2021. "Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia" Viruses 13, no. 7: 1413. https://doi.org/10.3390/v13071413

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