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Brief Report

Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases

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Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
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János Szentágothai Research Center, University of Pécs, 7624 Pécs, Hungary
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Institute of Bioanalysis, Medical School, University of Pécs, 7624 Pécs, Hungary
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Fundeni Clinical Institute, Gastroenterology, Hepatology and Liver Transplant Department, 022328 Bucharest, Romania
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Doctoral School, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
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Heim Pál National Pediatric Institute, 1089 Budapest, Hungary
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Doctoral School of Theoretical Medicine, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary
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Division of Infectious Diseases, First Department of Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
*
Authors to whom correspondence should be addressed.
The authors contributed equally to this work.
Academic Editor: Oliver Schildgen
Viruses 2021, 13(3), 512; https://doi.org/10.3390/v13030512
Received: 28 February 2021 / Revised: 15 March 2021 / Accepted: 16 March 2021 / Published: 19 March 2021
(This article belongs to the Section SARS-CoV-2 and COVID-19)
Repeated positivity and reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a significant concern. Our study aimed to evaluate the clinical significance of repeatedly positive testing after coronavirus disease 2019 (COVID-19) recovery. We performed a systematic literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. With available individual patient data reporting on repeatedly SARS-CoV-2 positive (RSP) patients, case reports, and case series were included in this analysis. We performed a descriptive analysis of baseline characteristics of repeatedly positive cases. We assessed the cases according to the length of their polymerase chain reaction (PCR) negative interval between the two episodes. Risk factors for the severity of second episodes were evaluated. Overall, we included 123 patients with repeated positivity from 56 publications, with a mean repeated positivity length of 47.8 ± 29.9 days. Younger patients were predominant in the delayed (>90 days) recurrent positive group. Furthermore, comparing patients with RSP intervals of below 60 and above 60 days, we found that a more severe disease course can be expected if the repeated positivity interval is shorter. Severe and critical disease courses might predict future repeatedly positive severe and critical COVID-19 episodes. In conclusion, our results show that the second episode of SARS-CoV-2 positivity is more severe if it happens within 60 days after the first positive PCR. On the other hand, the second episode’s severity correlates with the first. View Full-Text
Keywords: SARS-CoV-2; COVID-19; new coronavirus; polymerase chain reaction; positive; repeated; case reports; systematic review SARS-CoV-2; COVID-19; new coronavirus; polymerase chain reaction; positive; repeated; case reports; systematic review
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MDPI and ACS Style

Váncsa, S.; Dembrovszky, F.; Farkas, N.; Szakó, L.; Teutsch, B.; Bunduc, S.; Nagy, R.; Párniczky, A.; Erőss, B.; Péterfi, Z.; Hegyi, P. Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases. Viruses 2021, 13, 512. https://doi.org/10.3390/v13030512

AMA Style

Váncsa S, Dembrovszky F, Farkas N, Szakó L, Teutsch B, Bunduc S, Nagy R, Párniczky A, Erőss B, Péterfi Z, Hegyi P. Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases. Viruses. 2021; 13(3):512. https://doi.org/10.3390/v13030512

Chicago/Turabian Style

Váncsa, Szilárd, Fanni Dembrovszky, Nelli Farkas, Lajos Szakó, Brigitta Teutsch, Stefania Bunduc, Rita Nagy, Andrea Párniczky, Bálint Erőss, Zoltán Péterfi, and Péter Hegyi. 2021. "Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases" Viruses 13, no. 3: 512. https://doi.org/10.3390/v13030512

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