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Review

Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins

1
Division of Virology, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
2
Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
3
Department of Physiology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
*
Authors to whom correspondence should be addressed.
Viruses 2020, 12(2), 175; https://doi.org/10.3390/v12020175
Received: 16 December 2019 / Revised: 2 February 2020 / Accepted: 3 February 2020 / Published: 4 February 2020
(This article belongs to the Special Issue Hepatitis B Virus: From Diagnostics to Treatments)
Around 350 million people are living with hepatitis B virus (HBV), which can lead to death due to liver cirrhosis and hepatocellular carcinoma (HCC). Various antiviral drugs/nucleot(s)ide analogues are currently used to reduce or arrest the replication of this virus. However, many studies have reported that nucleot(s)ide analogue-resistant HBV is circulating. Cellular signaling pathways could be one of the targets against the viral replication. Several studies reported that viral proteins interacted with mitochondrial proteins and localized in the mitochondria, the powerhouse of the cell. And a recent study showed that mitochondrial turnover induced by thyroid hormones protected hepatocytes from hepatocarcinogenesis mediated by HBV. Strong downregulation of numerous cellular signaling pathways has also been reported to be accompanied by profound mitochondrial alteration, as confirmed by transcriptome profiling of HBV-specific CD8 T cells from chronic and acute HBV patients. In this review, we summarize the ongoing research into mitochondrial proteins and/or signaling involved with HBV proteins, which will continue to provide insight into the relationship between mitochondria and HBV and ultimately lead to advances in viral pathobiology and mitochondria-targeted antiviral therapy. View Full-Text
Keywords: Hepatitis B virus (HBV); mitochondria; proteins/signaling; interaction Hepatitis B virus (HBV); mitochondria; proteins/signaling; interaction
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MDPI and ACS Style

Hossain, M.G.; Akter, S.; Ohsaki, E.; Ueda, K. Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins. Viruses 2020, 12, 175. https://doi.org/10.3390/v12020175

AMA Style

Hossain MG, Akter S, Ohsaki E, Ueda K. Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins. Viruses. 2020; 12(2):175. https://doi.org/10.3390/v12020175

Chicago/Turabian Style

Hossain, Md. G., Sharmin Akter, Eriko Ohsaki, and Keiji Ueda. 2020. "Impact of the Interaction of Hepatitis B Virus with Mitochondria and Associated Proteins" Viruses 12, no. 2: 175. https://doi.org/10.3390/v12020175

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