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Open AccessCommunication

ABCE1 Acts as a Positive Regulator of Exogenous RNA Decay

1
Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
2
Laboratory of Immunosenescence, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki-City, Osaka 567-0085, Japan
3
Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
4
Department of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, Aichi 470-0392, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2020, 12(2), 174; https://doi.org/10.3390/v12020174
Received: 12 December 2019 / Revised: 14 January 2020 / Accepted: 3 February 2020 / Published: 4 February 2020
(This article belongs to the Special Issue Viruses and the OAS-RNase L Pathway)
The 2′-5′-oligoadenylate synthetase (OAS)/RNase L system protects hosts against pathogenic viruses through cleavage of the exogenous single-stranded RNA. In this system, an evolutionally conserved RNA quality control factor Dom34 (known as Pelota (Pelo) in higher eukaryotes) forms a surveillance complex with RNase L to recognize and eliminate the exogenous RNA in a manner dependent on translation. Here, we newly identified that ATP-binding cassette sub-family E member 1 (ABCE1), which is also known as RNase L inhibitor (RLI), is involved in the regulation of exogenous RNA decay. ABCE1 directly binds to form a complex with RNase L and accelerates RNase L dimer formation in the absence of 2′-5′ oligoadenylates (2-5A). Depletion of ABCE1 represses 2-5A-induced RNase L activation and stabilizes exogenous RNA to a level comparable to that seen in RNase L depletion. The increased half-life of the RNA by the single depletion of either protein is not significantly affected by the double depletion of both proteins, suggesting that RNase L and ABCE1 act together to eliminate exogenous RNA. Our results indicate that ABCE1 functions as a positive regulator of exogenous RNA decay rather than an inhibitor of RNase L. View Full-Text
Keywords: ABCE1; oligoadenylate synthetase; Ribonuclease L; exogenous RNA; RNA quality control ABCE1; oligoadenylate synthetase; Ribonuclease L; exogenous RNA; RNA quality control
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MDPI and ACS Style

Nogimori, T.; Ogami, K.; Oishi, Y.; Goda, R.; Hosoda, N.; Kitamura, Y.; Kitade, Y.; Hoshino, S.-i. ABCE1 Acts as a Positive Regulator of Exogenous RNA Decay. Viruses 2020, 12, 174. https://doi.org/10.3390/v12020174

AMA Style

Nogimori T, Ogami K, Oishi Y, Goda R, Hosoda N, Kitamura Y, Kitade Y, Hoshino S-i. ABCE1 Acts as a Positive Regulator of Exogenous RNA Decay. Viruses. 2020; 12(2):174. https://doi.org/10.3390/v12020174

Chicago/Turabian Style

Nogimori, Takuto; Ogami, Koichi; Oishi, Yuka; Goda, Ryoya; Hosoda, Nao; Kitamura, Yoshiaki; Kitade, Yukio; Hoshino, Shin-ichi. 2020. "ABCE1 Acts as a Positive Regulator of Exogenous RNA Decay" Viruses 12, no. 2: 174. https://doi.org/10.3390/v12020174

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