Next Article in Journal
Development of American-Lineage Influenza H5N2 Reassortant Vaccine Viruses for Pandemic Preparedness
Next Article in Special Issue
Host Immune Response to ZIKV in an Immunocompetent Embryonic Mouse Model of Intravaginal Infection
Previous Article in Journal
The Interplay between Host Innate Immunity and Hepatitis E Virus
Previous Article in Special Issue
Detection of a Novel Phlebovirus (Drin Virus) from Sand Flies in Albania
Open AccessArticle

Presence of Antibodies against Sindbis Virus in the Israeli Population: A Nationwide Cross-Sectional Study

by Ravit Koren 1,†, Ravit Bassal 2,†, Tamy Shohat 2,3, Daniel Cohen 3, Orna Mor 1,3, Ella Mendelson 1,3,† and Yaniv Lustig 1,*,†
1
Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical center, Tel-Hashomer 52621, Israel
2
Israel Center for Disease Control, Ministry of Health, Chaim Sheba Medical center, Tel-Hashomer 52621, Israel
3
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(6), 542; https://doi.org/10.3390/v11060542
Received: 18 March 2019 / Revised: 5 June 2019 / Accepted: 7 June 2019 / Published: 11 June 2019
(This article belongs to the Special Issue Emerging Arboviruses)
Sindbis virus (SINV) is a mosquito-borne alphavirus circulating globally. SINV outbreaks have been mainly reported in North-European countries. In Israel, SINV was detected in 6.3% of mosquito pools; however, SINV infection in humans has rarely been diagnosed. A serologic survey to detect SINV IgG antibodies was conducted to evaluate the seroprevalence of SINV in the Israeli population. In total, 3145 serum samples collected in 2011–2014, representing all age and population groups in Israel, were assessed using an indirect ELISA assay, and a neutralization assay was performed on all ELISA-positive samples. The prevalence rates of SINV IgG antibodies were calculated. Logistic regressions models were applied to assess the association between demographic characteristics and SINV seropositivity. Overall, 113 (3.6%) and 59 (1.9%) samples were positive for ELISA and neutralization SINV IgG, respectively. Multivariable analysis demonstrated that SINV seropositivity was significantly associated with older age and residence outside metropolitan areas. These results demonstrate that, despite no outbreaks or clinical presentation, SINV infects the human population in Israel. Seropositivity is countrywide, more frequent in people of older age, and less diffuse in Israel’s metropolitan areas. Seroprevalence studies from other countries will add to our understanding of the global burden of SINV and the risk for potential SINV outbreaks. View Full-Text
Keywords: Sindbis virus; seroprevalence; Sindbis disease; Israel; cross-sectional study Sindbis virus; seroprevalence; Sindbis disease; Israel; cross-sectional study
Show Figures

Figure 1

MDPI and ACS Style

Koren, R.; Bassal, R.; Shohat, T.; Cohen, D.; Mor, O.; Mendelson, E.; Lustig, Y. Presence of Antibodies against Sindbis Virus in the Israeli Population: A Nationwide Cross-Sectional Study. Viruses 2019, 11, 542.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop